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    RSPH10B radial spoke head 10 homolog B [ Homo sapiens (human) ]

    Gene ID: 222967, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RSPH10Bprovided by HGNC
    Official Full Name
    radial spoke head 10 homolog Bprovided by HGNC
    Primary source
    HGNC:HGNC:27362
    See related
    Ensembl:ENSG00000155026 AllianceGenome:HGNC:27362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable kinase activity. Predicted to be located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 16.5) See more
    Orthologs
    all
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    Genomic context

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    See RSPH10B in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5926136..5970851, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6043889..6088454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5965767..6010320, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5871051-5871551 Neighboring gene zinc finger protein 815, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1711 Neighboring gene RNA, 7SL, cytoplasmic 556, pseudogene Neighboring gene oncomodulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25613 Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene nonconserved acetylation island sequence 61 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25615 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Radial spoke proteins of Chlamydomonas flagella. Yang P, et al. J Cell Sci, 2006 Mar 15. PMID 16507594, Free PMC Article
    2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    3. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Mahlokozera T, et al. Nat Commun, 2021 Nov 3. PMID 34732716, Free PMC Article
    4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
    5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of radial spoke head 10 homolog B (RSPH10B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC50833

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head 10 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173565.5 → NP_775836.4  radial spoke head 10 homolog B

      Status: VALIDATED

      Source sequence(s)
      AC004983, AC005995
      Consensus CDS
      CCDS34598.1
      UniProtKB/Swiss-Prot
      A6NMW7, P0C881, Q86ST9, Q8NE68
      Related
      ENSP00000384097.1, ENST00000404406.6
      Conserved Domains (2) summary
      PLN03185
      Location:128 → 335
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      5926136..5970851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515208.4 → XP_011513510.1  radial spoke head 10 homolog B isoform X3

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    2. XM_011515204.3 → XP_011513506.1  radial spoke head 10 homolog B isoform X1

      See identical proteins and their annotated locations for XP_011513506.1

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    3. XM_024446691.2 → XP_024302459.1  radial spoke head 10 homolog B isoform X1

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    4. XM_011515209.4 → XP_011513511.1  radial spoke head 10 homolog B isoform X4

      Conserved Domains (1) summary
      PLN03185
      Location:106 → 320
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    5. XM_005249659.5 → XP_005249716.1  radial spoke head 10 homolog B isoform X2

      See identical proteins and their annotated locations for XP_005249716.1

      UniProtKB/Swiss-Prot
      A6NMW7, P0C881, Q86ST9, Q8NE68
      Conserved Domains (2) summary
      PLN03185
      Location:128 → 335
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    6. XM_011515207.1 → XP_011513509.1  radial spoke head 10 homolog B isoform X1

      See identical proteins and their annotated locations for XP_011513509.1

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    7. XM_011515203.1 → XP_011513505.1  radial spoke head 10 homolog B isoform X1

      See identical proteins and their annotated locations for XP_011513505.1

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    8. XM_047420047.1 → XP_047276003.1  radial spoke head 10 homolog B isoform X7

      UniProtKB/TrEMBL
      B3KSE9

    9. XM_011515210.1 → XP_011513512.1  radial spoke head 10 homolog B isoform X6

      UniProtKB/TrEMBL
      B3KSE9
      Conserved Domains (1) summary
      PLN03185
      Location:11 → 126
      PLN03185; phosphatidylinositol phosphate kinase; Provisional

    10. XM_017011870.3 → XP_016867359.1  radial spoke head 10 homolog B isoform X5

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    11. XM_011515212.4 → XP_011513514.1  radial spoke head 10 homolog B isoform X8

      Conserved Domains (2) summary
      PLN03185
      Location:128 → 318
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      COG4642
      Location:86 → 162
      COG4642; Uncharacterized conserved protein [Function unknown]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6043889..6088454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357600.1 → XP_054213575.1  radial spoke head 10 homolog B isoform X4

    2. XM_054357601.1 → XP_054213576.1  radial spoke head 10 homolog B isoform X4

    3. XM_054357596.1 → XP_054213571.1  radial spoke head 10 homolog B isoform X1

    4. XM_054357597.1 → XP_054213572.1  radial spoke head 10 homolog B isoform X1

    5. XM_054357595.1 → XP_054213570.1  radial spoke head 10 homolog B isoform X1

    6. XM_054357598.1 → XP_054213573.1  radial spoke head 10 homolog B isoform X2

    7. XM_054357599.1 → XP_054213574.1  radial spoke head 10 homolog B isoform X3

    8. XM_054357594.1 → XP_054213569.1  radial spoke head 10 homolog B isoform X1

    9. XM_054357603.1 → XP_054213578.1  radial spoke head 10 homolog B isoform X6

      UniProtKB/TrEMBL
      B3KSE9

    10. XM_054357602.1 → XP_054213577.1  radial spoke head 10 homolog B isoform X5

    11. XM_054357604.1 → XP_054213579.1  radial spoke head 10 homolog B isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C881.1 GenPept UniProtKB/Swiss-Prot:P0C881

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