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    PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 [ Homo sapiens (human) ]

    Gene ID: 9677, updated on 4-Jan-2025

    Summary

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    Official Symbol
    PPIP5K1provided by HGNC
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:29023
    See related
    Ensembl:ENSG00000168781 MIM:610979; AllianceGenome:HGNC:29023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IP6K; IPS1; VIP1; hsVIP1; HISPPD2A
    Summary
    This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in duodenum (RPKM 8.8), small intestine (RPKM 8.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPIP5K1 in Genome Data Viewer
    Location:
    15q15.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43533475..43590253, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41340826..41397612, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43825673..43882451, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43810281-43810924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43819912-43820544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43821526-43822026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43822027-43822527 Neighboring gene microtubule associated protein 1A Neighboring gene RNA, U6 small nuclear 554, pseudogene Neighboring gene creatine kinase, mitochondrial 1B Neighboring gene stereocilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family. Shears SB, et al. Adv Biol Regul, 2017 Jan. PMID 27776974, Free PMC Article
    2. PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility. Machkalyan G, et al. Cell Signal, 2016 May. PMID 26854614
    3. Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Gokhale NA, et al. Biochem J, 2011 Mar 15. PMID 21222653, Free PMC Article
    4. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. Gu C, et al. J Biol Chem, 2017 Mar 17. PMID 28126903, Free PMC Article
    5. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. Choi JH, et al. J Biol Chem, 2007 Oct 19. PMID 17702752, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPIP5K is a rare example of a single protein that catalyzes a kinase/phosphatase futile cycle. (Review)
      Title: The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family.
    2. This study characterized kinetic properties of the bifunctional inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphatekinase/inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate phosphatase activities of full-length diphosphoinositol pentakisphosphate kinase 1 and 2.
      Title: The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.
    3. results suggest that PPIP5K1 might play an important role in regulating function of exocyst complex in establishing cellular polarity and directional migration of cells
      Title: PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.
    4. Upon activation of the appropriate cell-surface receptors to stimulate PtdIns(3,4,5)P3 synthesis, human PPIP5K1 translocates from the cytoplasm to the plasma membrane.
      Title: Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0377, MGC51871, DKFZp313L0221

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
    Names
    IP6 kinase
    VIP1 homolog
    histidine acid phosphatase domain containing 2A
    histidine acid phosphatase domain-containing protein 2A
    inositol pyrophosphate synthase 1
    insP6 and PP-IP5 kinase 1
    NP_001124330.1
    NP_001124331.1
    NP_001177143.1
    NP_001341311.1
    NP_001341312.1
    NP_001341313.1
    NP_001341314.1
    NP_001341315.1
    NP_001341316.1
    NP_001341317.1
    NP_001341318.1
    NP_001341319.1
    NP_001341320.1
    NP_001341321.1
    NP_001341322.1
    NP_001341323.1
    NP_001341324.1
    NP_001341325.1
    NP_001341326.1
    NP_001341327.1
    NP_001341328.1
    NP_001341329.1
    NP_001341330.1
    NP_001341331.1
    NP_001380898.1
    NP_001380899.1
    NP_001380900.1
    NP_001381324.1
    NP_055474.3
    XP_005254861.1
    XP_006720849.1
    XP_011520551.1
    XP_011520552.1
    XP_011520554.1
    XP_011520556.1
    XP_011520560.1
    XP_016878225.1
    XP_016878226.1
    XP_016878236.1
    XP_016878242.1
    XP_016878243.1
    XP_047289332.1
    XP_047289333.1
    XP_047289334.1
    XP_047289335.1
    XP_047289336.1
    XP_047289337.1
    XP_047289338.1
    XP_047289339.1
    XP_047289340.1
    XP_047289341.1
    XP_047289342.1
    XP_047289343.1
    XP_047289344.1
    XP_047289345.1
    XP_047289346.1
    XP_054235239.1
    XP_054235240.1
    XP_054235241.1
    XP_054235242.1
    XP_054235243.1
    XP_054235244.1
    XP_054235245.1
    XP_054235246.1
    XP_054235247.1
    XP_054235248.1
    XP_054235249.1
    XP_054235250.1
    XP_054235251.1
    XP_054235252.1
    XP_054235253.1
    XP_054235254.1
    XP_054235255.1
    XP_054235256.1
    XP_054235257.1
    XP_054235258.1
    XP_054235259.1
    XP_054235260.1
    XP_054235261.1
    XP_054235262.1
    XP_054235263.1
    XP_054235264.1
    XP_054235265.1
    XP_054235266.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_022929.1 RefSeqGene

      Range
      5046..61779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130858.4 → NP_001124330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS45252.1
      UniProtKB/Swiss-Prot
      O15082, Q5HYF8, Q6PFW1, Q7Z3A7, Q86TE7, Q86UV3, Q86UV4, Q86XW8, Q8IZN0
      UniProtKB/TrEMBL
      F8W9A8
      Related
      ENSP00000380129.2, ENST00000396923.7
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 910
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    2. NM_001130859.3 → NP_001124331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011330, BC057395, BX538022, DB065605
      Consensus CDS
      CCDS32215.1
      UniProtKB/TrEMBL
      F8W9A8
      Related
      ENSP00000334779.4, ENST00000334933.8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    3. NM_001190214.2 → NP_001177143.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AB002375, AC011330, AC019011, AI638651, DB065605
      Consensus CDS
      CCDS53937.1
      UniProtKB/TrEMBL
      F8W9A8
      Related
      ENSP00000353253.4, ENST00000360135.8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    4. NM_001354382.3 → NP_001341311.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS86452.1
      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Related
      ENSP00000371309.1, ENST00000381885.5
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    5. NM_001354383.2 → NP_001341312.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS86452.1
      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    6. NM_001354384.2 → NP_001341313.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS86452.1
      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    7. NM_001354385.2 → NP_001341314.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS86452.1
      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    8. NM_001354386.2 → NP_001341315.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS86452.1
      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    9. NM_001354387.2 → NP_001341316.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 898
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    10. NM_001354388.2 → NP_001341317.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 898
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    11. NM_001354389.2 → NP_001341318.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 898
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    12. NM_001354390.2 → NP_001341319.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS32215.1
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    13. NM_001354391.2 → NP_001341320.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS32215.1
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    14. NM_001354392.2 → NP_001341321.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS32215.1
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    15. NM_001354393.2 → NP_001341322.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 898
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    16. NM_001354394.2 → NP_001341323.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 878
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    17. NM_001354395.2 → NP_001341324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    18. NM_001354396.2 → NP_001341325.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    19. NM_001354397.2 → NP_001341326.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    20. NM_001354398.2 → NP_001341327.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:135 → 651
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    21. NM_001354399.2 → NP_001341328.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:135 → 651
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    22. NM_001354400.2 → NP_001341329.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:135 → 651
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    23. NM_001354401.2 → NP_001341330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Conserved Domains (2) summary
      cl11399
      Location:5 → 242
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cl27087
      Location:547 → 654
      SPOR; Sporulation related domain

    24. NM_001354402.2 → NP_001341331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Conserved Domains (2) summary
      cl11399
      Location:5 → 234
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
      cl27087
      Location:518 → 625
      SPOR; Sporulation related domain

    25. NM_001393969.1 → NP_001380898.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      A0A9L9PYJ9, F8W9A8
      Conserved Domains (2) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:55 → 144
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    26. NM_001393970.1 → NP_001380899.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      A0A9L9PYJ9, F8W9A8
      Related
      ENSP00000516724.1, ENST00000707073.1
      Conserved Domains (2) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:55 → 144
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    27. NM_001393971.1 → NP_001380900.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      cd07061
      Location:525 → 894
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    28. NM_001394395.1 → NP_001381324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS91989.1
      UniProtKB/TrEMBL
      A0A8J8ZH50, F8W9A8
      Related
      ENSP00000400887.2, ENST00000420765.6
      Conserved Domains (1) summary
      cd07061
      Location:525 → 902
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    29. NM_014659.6 → NP_055474.3  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011330, AC019011
      Consensus CDS
      CCDS32215.1
      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      43533475..43590253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433387.1 → XP_047289343.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8

    2. XM_047433384.1 → XP_047289340.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

      UniProtKB/TrEMBL
      F8W9A8

    3. XM_047433381.1 → XP_047289337.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

      UniProtKB/TrEMBL
      B7WPL9, F8W9A8
      Related
      ENSP00000371303.4, ENST00000381879.8

    4. XM_047433380.1 → XP_047289336.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A9L9PYJ9, F8W9A8

    5. XM_011522254.2 → XP_011520556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    6. XM_047433377.1 → XP_047289333.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    7. XM_017022753.2 → XP_016878242.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 898
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    8. XM_011522252.2 → XP_011520554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    9. XM_047433390.1 → XP_047289346.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

      UniProtKB/TrEMBL
      F8W9A8

    10. XM_047433379.1 → XP_047289335.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

      UniProtKB/TrEMBL
      F8W9A8

    11. XM_006720786.3 → XP_006720849.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    12. XM_005254804.1 → XP_005254861.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

      UniProtKB/TrEMBL
      F8W9A8
      Related
      ENSP00000353446.4, ENST00000360301.8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    13. XM_011522249.1 → XP_011520551.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    14. XM_047433389.1 → XP_047289345.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    15. XM_047433382.1 → XP_047289338.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

      UniProtKB/TrEMBL
      B7WPL9, F8W9A8

    16. XM_047433386.1 → XP_047289342.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8

    17. XM_047433383.1 → XP_047289339.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

      UniProtKB/TrEMBL
      F8W9A8

    18. XM_017022754.2 → XP_016878243.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    19. XM_047433385.1 → XP_047289341.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

      UniProtKB/TrEMBL
      F8W9A8

    20. XM_047433376.1 → XP_047289332.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    21. XM_017022737.2 → XP_016878226.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    22. XM_047433388.1 → XP_047289344.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    23. XM_011522250.2 → XP_011520552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    24. XM_017022736.2 → XP_016878225.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    25. XM_047433378.1 → XP_047289334.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    26. XM_017022747.2 → XP_016878236.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:390 → 906
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    27. XM_011522258.2 → XP_011520560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

      UniProtKB/TrEMBL
      F8W9A8
      Conserved Domains (1) summary
      pfam00328
      Location:135 → 651
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      41340826..41397612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379284.1 → XP_054235259.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8

    2. XM_054379278.1 → XP_054235253.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

      UniProtKB/TrEMBL
      F8W9A8

    3. XM_054379275.1 → XP_054235250.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

      UniProtKB/TrEMBL
      B7WPL9, F8W9A8

    4. XM_054379274.1 → XP_054235249.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A9L9PYJ9, F8W9A8

    5. XM_054379268.1 → XP_054235243.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    6. XM_054379270.1 → XP_054235245.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    7. XM_054379283.1 → XP_054235258.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8

    8. XM_054379266.1 → XP_054235241.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    9. XM_054379289.1 → XP_054235264.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

      UniProtKB/TrEMBL
      F8W9A8

    10. XM_054379273.1 → XP_054235248.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

      UniProtKB/TrEMBL
      F8W9A8

    11. XM_054379285.1 → XP_054235260.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    12. XM_054379280.1 → XP_054235255.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

      UniProtKB/TrEMBL
      F8W9A8

    13. XM_054379264.1 → XP_054235239.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    14. XM_054379288.1 → XP_054235263.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    15. XM_054379276.1 → XP_054235251.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

      UniProtKB/TrEMBL
      B7WPL9, F8W9A8

    16. XM_054379282.1 → XP_054235257.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      F8W9A8

    17. XM_054379277.1 → XP_054235252.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

      UniProtKB/TrEMBL
      F8W9A8

    18. XM_054379287.1 → XP_054235262.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    19. XM_054379281.1 → XP_054235256.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

      UniProtKB/TrEMBL
      F8W9A8

    20. XM_054379265.1 → XP_054235240.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    21. XM_054379267.1 → XP_054235242.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    22. XM_054379286.1 → XP_054235261.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

      UniProtKB/TrEMBL
      F8W9A8

    23. XM_054379271.1 → XP_054235246.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    24. XM_054379269.1 → XP_054235244.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    25. XM_054379272.1 → XP_054235247.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/TrEMBL
      F8W9A8

    26. XM_054379279.1 → XP_054235254.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

      UniProtKB/TrEMBL
      F8W9A8

    27. XM_054379290.1 → XP_054235265.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

      UniProtKB/TrEMBL
      F8W9A8

    28. XM_054379291.1 → XP_054235266.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X12

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024463.3: Suppressed sequence

      Description
      NM_001024463.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns to the reference genome with non-consensus splice sites.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFW1.1 GenPept UniProtKB/Swiss-Prot:Q6PFW1

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