FCGR1A Fc gamma receptor Ia [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCGR1Aprovided by HGNC
Official Full Name: Fc gamma receptor Iaprovided by HGNC
Primary source: HGNC:HGNC:3613
See related: Ensembl:ENSG00000150337 MIM:146760; AllianceGenome:HGNC:3613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD64; FCG1; FCRI; CD64A; FCGR1; IGFR1; FcgammaRI
Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Expression: Biased expression in appendix (RPKM 19.0), placenta (RPKM 13.4) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (149782694..149800609)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (148906840..148924747)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (149754250..149772165)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
Title: Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.
A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
Title: A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso.
Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
Title: Prognostic performance of neutrophil CD64 expression in patients with complicated intra-abdominal infections - a prospective study.
CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
Title: CD64 expression on neutrophils as a potential biomarker for bacterial infection in ascitic fluid of cirrhotic patients.
Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
Title: Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study.
Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
Title: Novel Human FCGR1A Variants Affect CD64 Functions and Are Risk Factors for Sarcoidosis.
Soluble FcgammaRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
Title: Soluble FcγRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.
Fcgamma receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
Title: Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development.
Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
Title: Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.
CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
Title: CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.

Submit: New GeneRIF Correction See all GeneRIFs (133)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120	PubMed
Nef	nef	HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69162 (e-PCR)
- UniSTS:87555

D1S3356 (e-PCR)
- UniSTS:58324

GDB:190043 (e-PCR)
- UniSTS:155613

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	IEA Inferred from Electronic Annotation more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables high-affinity IgG receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibody-dependent cellular cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, recognition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type III hypersensitivity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type IIa hypersensitivity	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in early endosome membrane	TAS Traceable Author Statement more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: high affinity immunoglobulin gamma Fc receptor I

Names: Fc fragment of IgG receptor Ia; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor for (CD64); Fc-gamma RI; Fc-gamma receptor I A1; IgG Fc receptor I; fc-gamma RIA; fcgammaRIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007578.1 RefSeqGene

Range

4963..14787

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_59

mRNA and Protein(s)

NM_000566.4 → NP_000557.1 high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor

See identical proteins and their annotated locations for NP_000557.1

Status: REVIEWED

Source sequence(s)

AC243772

Consensus CDS

CCDS933.1

UniProtKB/Swiss-Prot

P12314, P12315, Q5QNW7, Q92495, Q92663

Related

ENSP00000358165.4, ENST00000369168.5

Conserved Domains (3) summary

cd05752
Location:22 → 100

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:104 → 185

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

pfam00047
Location:196 → 274

ig; Immunoglobulin domain
NM_001378804.1 → NP_001365733.1 high affinity immunoglobulin gamma Fc receptor I isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC243772

Conserved Domains (3) summary

pfam00047
Location:197 → 275

ig; Immunoglobulin domain

cd05752
Location:23 → 101

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:105 → 186

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378805.1 → NP_001365734.1 high affinity immunoglobulin gamma Fc receptor I isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC243772

Conserved Domains (3) summary

pfam00047
Location:189 → 267

ig; Immunoglobulin domain

cd05752
Location:15 → 93

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:97 → 178

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378806.1 → NP_001365735.1 high affinity immunoglobulin gamma Fc receptor I isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC243772

Conserved Domains (3) summary

pfam00047
Location:196 → 274

ig; Immunoglobulin domain

cd05752
Location:22 → 100

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:104 → 185

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378807.1 → NP_001365736.1 high affinity immunoglobulin gamma Fc receptor I isoform 5

Status: REVIEWED

Source sequence(s)

AC243772

Conserved Domains (3) summary

pfam00047
Location:173 → 251

ig; Immunoglobulin domain

cd05752
Location:5 → 77

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cd05753
Location:81 → 162

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378808.1 → NP_001365737.1 high affinity immunoglobulin gamma Fc receptor I isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC243772

Conserved Domains (2) summary

pfam00047
Location:112 → 190

ig; Immunoglobulin domain

cd05752
Location:22 → 100

Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378809.1 → NP_001365738.1 high affinity immunoglobulin gamma Fc receptor I isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC243772

UniProtKB/TrEMBL

C9JSN8

Conserved Domains (3) summary

pfam00047
Location:111 → 189

ig; Immunoglobulin domain

cd00096
Location:122 → 128

Ig; Ig strand B [structural motif]

cd05753
Location:19 → 100

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378810.1 → NP_001365739.1 high affinity immunoglobulin gamma Fc receptor I isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AC243772

UniProtKB/TrEMBL

C9JSN8

Related

ENSP00000394279.1, ENST00000444948.5

Conserved Domains (3) summary

pfam00047
Location:104 → 182

ig; Immunoglobulin domain

cd00096
Location:115 → 121

Ig; Ig strand B [structural motif]

cd05753
Location:16 → 93

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
NM_001378811.1 → NP_001365740.1 high affinity immunoglobulin gamma Fc receptor I isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AC243772

UniProtKB/TrEMBL

C9JSN8

Conserved Domains (3) summary

pfam00047
Location:104 → 182

ig; Immunoglobulin domain

cd00096
Location:115 → 121

Ig; Ig strand B [structural motif]

cd05753
Location:16 → 93

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains