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    PRXL2A peroxiredoxin like 2A [ Homo sapiens (human) ]

    Gene ID: 84293, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRXL2Aprovided by HGNC
    Official Full Name
    peroxiredoxin like 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:28651
    See related
    Ensembl:ENSG00000122378 MIM:617165; AllianceGenome:HGNC:28651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Adrx; PAMM; FAM213A; C10orf58
    Summary
    Enables antioxidant activity. Involved in regulation of osteoclast differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in fat (RPKM 75.6), brain (RPKM 14.4) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRXL2A in Genome Data Viewer
    Location:
    10q23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80407829..80437115)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81276927..81306214)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82167585..82196871)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene MPRA-validated peak1026 silencer Neighboring gene DPY30 domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82123032-82123216 Neighboring gene DPY30 domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82163430-82163602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82168661-82169254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82170101-82170600 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:82177040-82177582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3654 Neighboring gene Sharpr-MPRA regulatory region 12974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82214375-82214892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3659 Neighboring gene Sharpr-MPRA regulatory region 907 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82224527-82225098 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82225099-82225670 Neighboring gene Sharpr-MPRA regulatory region 4556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3660 Neighboring gene tetraspanin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2547 Neighboring gene Sharpr-MPRA regulatory region 2609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82257110-82258073 Neighboring gene Sharpr-MPRA regulatory region 10623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3664 Neighboring gene uncharacterized LOC124902471 Neighboring gene TSPAN14 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4248, FLJ12536, FLJ14952, FLJ44312

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antioxidant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peroxiredoxin-like 2A
    Names
    Adiporedoxin
    UPF0765 protein C10orf58
    family with sequence similarity 213 member A
    peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes
    peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
    redox-regulatory protein FAM213A
    redox-regulatory protein PAMM

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243778.2NP_001230707.1  peroxiredoxin-like 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001230707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AA829725, AC021028, AL359195, BC005871
      Consensus CDS
      CCDS7368.1
      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Related
      ENSP00000361261.5, ENST00000372187.9
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    2. NM_001243779.2NP_001230708.1  peroxiredoxin-like 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001230708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1)
      Source sequence(s)
      AA829725, AC021028, AF305824, BC005871, BE742158
      Consensus CDS
      CCDS7368.1
      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Related
      ENSP00000361262.1, ENST00000372188.5
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    3. NM_001243780.2NP_001230709.1  peroxiredoxin-like 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001230709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AA829725, AC021028, BC024308, DB494833
      Consensus CDS
      CCDS7368.1
      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Related
      ENSP00000478152.1, ENST00000615554.4
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    4. NM_001243781.2NP_001230710.1  peroxiredoxin-like 2A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001230710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA829725, AC021028, AK075447, BC005871
      Consensus CDS
      CCDS58089.1
      UniProtKB/Swiss-Prot
      Q9BRX8
      Related
      ENSP00000361259.1, ENST00000372185.5
      Conserved Domains (1) summary
      cd02970
      Location:37190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    5. NM_001243782.2NP_001230711.1  peroxiredoxin-like 2A isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA829725, AC021028, AL359195, BC005871, CN396006
      UniProtKB/Swiss-Prot
      Q9BRX8
      Conserved Domains (1) summary
      cd02970
      Location:44197
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    6. NM_032333.5NP_115709.3  peroxiredoxin-like 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_115709.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AA829725, AC021028, AI589570, AK074643, BC071938
      Consensus CDS
      CCDS7368.1
      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Related
      ENSP00000482445.1, ENST00000606162.6
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      80407829..80437115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540266.3XP_011538568.1  peroxiredoxin-like 2A isoform X2

      See identical proteins and their annotated locations for XP_011538568.1

      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    2. XM_017016775.2XP_016872264.1  peroxiredoxin-like 2A isoform X1

      Conserved Domains (1) summary
      cd02970
      Location:55208
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    3. XM_011540265.3XP_011538567.1  peroxiredoxin-like 2A isoform X2

      See identical proteins and their annotated locations for XP_011538567.1

      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      81276927..81306214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366927.1XP_054222902.1  peroxiredoxin-like 2A isoform X1

    2. XM_054366929.1XP_054222904.1  peroxiredoxin-like 2A isoform X2

      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    3. XM_054366928.1XP_054222903.1  peroxiredoxin-like 2A isoform X2

      UniProtKB/Swiss-Prot
      B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8