Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3cgprovided by MGI
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by MGI
Primary source: MGI:MGI:1353576
See related: Ensembl:ENSMUSG00000020573 AllianceGenome:MGI:1353576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PI3Kgamma; p110gamma; p120-PI3K; 5830428L06Rik
Summary: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including G protein-coupled receptor signaling pathway; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of Rac protein signal transduction. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and protein phosphorylation. Predicted to be located in cytosol and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in future spinal cord; hemolymphoid system; and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 8.2), spleen adult (RPKM 4.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 13.74 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (32223128..32258675, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (32173397..32208677, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3Kgamma maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Title: PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury.
Title: PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury.
Hypoxia Sensing of beta-Adrenergic Receptor Is Regulated by Endosomal PI3Kgamma.
Title: Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.
Phosphoinositide 3 Kinase gamma Plays a Critical Role in Acute Kidney Injury.
Title: Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury.
A PI3Kgamma mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Title: A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
PI3Kgamma Mediates Microglial Proliferation and Cell Viability via ROS.
Title: PI3Kγ Mediates Microglial Proliferation and Cell Viability via ROS.
Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
Cannabidiol anticonvulsant effect is mediated by the PI3Kgamma pathway.
Title: Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.
Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice-role of phosphoinositide 3-kinase gamma.
Title: Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice-role of phosphoinositide 3-kinase gamma.
Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kalpha and PI3Kgamma.
Title: Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.

Submit: New GeneRIF Correction See all GeneRIFs (165)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB283666 (e-PCR)
- UniSTS:208794

D12Mit106 (e-PCR), detects polymorphism
- UniSTS:126656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to cAMP	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretory granule localization	IEA Inferred from Electronic Annotation more info
involved_in secretory granule localization	ISO Inferred from Sequence Orthology more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IA	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class IB	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IB	IEA Inferred from Electronic Annotation more info
part_of phosphatidylinositol 3-kinase complex, class IB	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Names: PI3-kinase subunit gamma; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphoinositide-3-kinase, catalytic, gamma polypeptide; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG

NP_001139672.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NP_001139673.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NP_064668.2

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_006515175.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_036013361.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

XP_036013362.1

EC 2.7.1.137

EC 2.7.1.153

EC 2.7.1.154

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146200.2 → NP_001139672.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_001139672.1

Status: VALIDATED

Source sequence(s)

AC140314, AK077772, AK137470, BY194814

Consensus CDS

CCDS25870.1

UniProtKB/Swiss-Prot

Q80V09, Q9JHG7

UniProtKB/TrEMBL

Q3UVA4, Q3V1C0

Related

ENSMUSP00000062864.8, ENSMUST00000053215.14

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
NM_001146201.2 → NP_001139673.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_001139673.1

Status: VALIDATED

Source sequence(s)

AC140314, AK077772, AK137470

Consensus CDS

CCDS25870.1

UniProtKB/Swiss-Prot

Q80V09, Q9JHG7

UniProtKB/TrEMBL

Q3UVA4, Q3V1C0

Related

ENSMUSP00000151400.2, ENSMUST00000220366.2

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
NM_020272.2 → NP_064668.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_064668.2

Status: VALIDATED

Source sequence(s)

AC140314, AK077772, AK137470

Consensus CDS

CCDS25870.1

UniProtKB/Swiss-Prot

Q80V09, Q9JHG7

UniProtKB/TrEMBL

Q3UVA4, Q3V1C0

Related

ENSMUSP00000082596.6, ENSMUST00000085469.6

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

RNA

NR_157094.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140314

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

32223128..32258675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515112.4 → XP_006515175.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

See identical proteins and their annotated locations for XP_006515175.1

UniProtKB/Swiss-Prot

Q80V09, Q9JHG7

UniProtKB/TrEMBL

Q3UVA4, Q3V1C0

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:729 → 1095

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_036157469.1 → XP_036013362.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X3

UniProtKB/TrEMBL

A0A1W2P8F6

Related

ENSMUSP00000152007.2, ENSMUST00000217915.2

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cl21453
Location:729 → 1014

PKc_like; Protein Kinases, catalytic domain
XM_036157468.1 → XP_036013361.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A0A1W2P8F6

Conserved Domains (4) summary

cd08399
Location:350 → 527

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:549 → 725

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cl21453
Location:729 → 1010

PKc_like; Protein Kinases, catalytic domain