Srgap1 SLIT-ROBO Rho GTPase activating protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srgap1provided by MGI
Official Full Name: SLIT-ROBO Rho GTPase activating protein 1provided by MGI
Primary source: MGI:MGI:2152936
See related: Ensembl:ENSMUSG00000020121 AllianceGenome:MGI:2152936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arhgap13; 4930572H05Rik
Summary: Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within Rho protein signal transduction and cell migration. Predicted to be active in cytoplasm. Is expressed in mesonephros mesenchyme; metanephros; nervous system; neural retina; and vomeronasal organ. Used to study focal segmental glomerulosclerosis. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 16.0), CNS E18 (RPKM 14.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 69.96 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (121616896..121883740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (121780991..122047911, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.
Title: SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.
Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract
Title: Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.
srGAP1 and srGAP3 are largely expressed in subpopulations of dorsal root ganglion neurons following sciatic nerve lesion.
Title: Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.
Data show that srGAP3 is expressed in ventricular zones of neurogenesis in many different tissues of the central nervous system.
Title: Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit268 (e-PCR), detects polymorphism
- UniSTS:160039

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SLIT-ROBO Rho GTPase-activating protein 1

Names: Rho GTPase activating protein 13; rho GTPase-activating protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081037.2 → NP_001074506.1 SLIT-ROBO Rho GTPase-activating protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC153494, AK138257, BU704234, BU706317, CB521559, CD351674, CV556288, CX569081

Consensus CDS

CCDS36075.1

UniProtKB/TrEMBL

D3YZW1

Related

ENSMUSP00000080389.7, ENSMUST00000081688.13

Conserved Domains (3) summary

cd07683
Location:26 → 278

F-BAR_srGAP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1

cd11955
Location:747 → 799

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:502 → 689

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
NM_001242411.1 → NP_001229340.1 SLIT-ROBO Rho GTPase-activating protein 1 isoform 2

See identical proteins and their annotated locations for NP_001229340.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate coding exon, that causes a frameshift; however, it contains an alternate downstream exon that restores the reading frame. The resulting isoform (2) has a different internal segment compared to isoform 1.

Source sequence(s)

AC153494, AK138257, BU704234, BU706317, CB521559, CD351674, CV556288, CX569081

Consensus CDS

CCDS56751.1

UniProtKB/Swiss-Prot

Q08E84, Q91Z69

Related

ENSMUSP00000020322.6, ENSMUST00000020322.12

Conserved Domains (3) summary

cd07683
Location:26 → 278

F-BAR_srGAP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1

cd11955
Location:724 → 776

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:482 → 666

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

121616896..121883740 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155558.1 → XP_036011451.1 SLIT-ROBO Rho GTPase-activating protein 1 isoform X1

Conserved Domains (3) summary

cd07683
Location:26 → 278

F-BAR_srGAP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1

cd11955
Location:612 → 664

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cl02570
Location:471 → 554

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...