Rhox3a reproductive homeobox 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox3aprovided by MGI
Official Full Name: reproductive homeobox 3Aprovided by MGI
Primary source: MGI:MGI:2676626
See related: Ensembl:ENSMUSG00000071772 AllianceGenome:MGI:2676626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prx; Rhox3; Gm1138; Rhox3.1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: This gene was previously named "Rhox3" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox3.1" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox3a. [07 Jan 2013]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X A3.3; X 21.67 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36513572..36522631)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37249919..37258978)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rhox3 shRNA causes spermatogenic defects by sequestering one or more components of the endogenous small RNA biogenesis machinery.
Title: shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: reproductive homeobox 3A

Names: reproductive homeobox 3; reproductive homeobox on X chromosome, 3; testis expressed homeobox 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194063.3 → NP_918952.2 reproductive homeobox 3A

See identical proteins and their annotated locations for NP_918952.2

Status: VALIDATED

Source sequence(s)

AL451076, DQ058640

Consensus CDS

CCDS30076.1

UniProtKB/TrEMBL

E9Q4C8, F6PYZ5, Q4TU90

Related

ENSMUSP00000110857.3, ENSMUST00000115203.10

Conserved Domains (1) summary

cd00086
Location:155 → 211

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.