Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tap2provided by MGI
Official Full Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
Primary source: MGI:MGI:98484
See related: Ensembl:ENSMUSG00000024339 AllianceGenome:MGI:98484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Y1; jas; APT2; Ham2; MTP2; PSF2; ABC18; Abcb3; Ham-2; Tap-2; RING11
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thymus adult (RPKM 79.3), spleen adult (RPKM 48.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34423453..34435295)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34204479..34216321)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study show that a new mouse strain with a single point mutation (Tap2 knock-out strain) shows impaired survival of macrophage survival following peritoneal iflammation
Title: A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.
The Rose strain has an A to T substitution in exon 10 of TAP1, resulting in an asparagine to valine substitution at position 643; defective TAP expression mice have very low major histocompatibility complex-I cell-surface expression, and few CD8 T cells.
Title: Mouse strains with point mutations in TAP1 and TAP2.
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
Title: A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tap2 (e-PCR), detects polymorphism
- UniSTS:474695

AI462429 (e-PCR)
- UniSTS:166053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type peptide antigen transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type peptide antigen transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type peptide transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
contributes_to MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein binding	IEA Inferred from Electronic Annotation more info
enables MHC class Ib protein binding	ISO Inferred from Sequence Orthology more info
enables TAP1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables TAP1 binding	ISO Inferred from Sequence Orthology more info
enables TAP2 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IEA Inferred from Electronic Annotation more info
contributes_to peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
contributes_to peptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables tapasin binding	ISO Inferred from Sequence Orthology more info
enables tapasin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytosol to endoplasmic reticulum transport	IEA Inferred from Electronic Annotation more info
involved_in cytosol to endoplasmic reticulum transport	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen transport	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen transport	ISO Inferred from Sequence Orthology more info
involved_in peptide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in protection from natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of TAP complex	IEA Inferred from Electronic Annotation more info
part_of TAP complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: antigen peptide transporter 2

Names: ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; histocompatibility antigen modifier 2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette)

NP_035660.3

EC 7.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011530.3 → NP_035660.3 antigen peptide transporter 2

See identical proteins and their annotated locations for NP_035660.3

Status: REVIEWED

Source sequence(s)

BE691532, CJ046345, M90459

Consensus CDS

CCDS28644.1

UniProtKB/Swiss-Prot

P36371

UniProtKB/TrEMBL

Q3TXM1, Q3UA79, Q61232, Q792S7, Q80WF7

Related

ENSMUSP00000025197.6, ENSMUST00000025197.6

Conserved Domains (3) summary

TIGR00958
Location:1 → 696

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:155 → 415

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:456 → 679

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases