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    H2-Ab1 histocompatibility 2, class II antigen A, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14961, updated on 10-Dec-2024

    Summary

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    Official Symbol
    H2-Ab1provided by MGI
    Official Full Name
    histocompatibility 2, class II antigen A, beta 1provided by MGI
    Primary source
    MGI:MGI:103070
    See related
    Ensembl:ENSMUSG00000073421 AllianceGenome:MGI:103070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta
    Summary
    Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Part of MHC class II protein complex. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Used to study dilated cardiomyopathy and myocarditis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 2279.6), large intestine adult (RPKM 1316.2) and 12 other tissues See more
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    Genomic context

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    See H2-Ab1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34482201..34488392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34263227..34269418)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4209 Neighboring gene STARR-positive B cell enhancer ABC_E4210 Neighboring gene histocompatibility 2, O region beta locus Neighboring gene STARR-positive B cell enhancer ABC_E7524 Neighboring gene predicted gene 20506 Neighboring gene STARR-positive B cell enhancer ABC_E768 Neighboring gene STARR-positive B cell enhancer ABC_E1193 Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficient contact hypersensitivity reaction in CD4-/- mice is because of impaired hapten-specific CD8+ T cell functions. Saint-Mezard P, et al. J Invest Dermatol, 2005 Mar. PMID 15737197
    2. Islet cell autoimmunity in NOD mice transgenic to HLA-DQ8 and lacking I-Ag7. Raju R, et al. Transplant Proc, 1998 Mar. PMID 9532134
    3. Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse. Suzuki M, et al. Int Immunol, 2012 Apr. PMID 22402880
    4. T cell responses in EAMG-susceptible and non-susceptible mouse strains after immunization with overlapping peptides encompassing the extracellular part of Torpedo californica acetylcholine receptor alpha chain. Implication to role in myasthenia gravis of autoimmune T-cell responses against receptor degradation products. Oshima M, et al. Autoimmunity, 1998. PMID 9583739
    5. Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. Stohl W, et al. Clin Immunol, 2005 Sep. PMID 15963762

    See all (896) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gut microbiota regulates blood-cerebrospinal fluid barrier function and Abeta pathology.
      Title: Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology.
    2. Two structurally defined Abeta polymorphs promote different pathological changes in susceptible mice.
      Title: Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice.
    3. Both the modest nature of the TLR2-mediated inflammatory response and the modulation of MHC-II expression by Brucella abortus may contribute to bacterial survival in alveolar macrophages.
      Title: Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages.
    4. Murine CD4+ T cells specific for Salmonella peptide/class II histocompatibility ligands are numerically stable for more than a year after initial oral infection with Salmonella.
      Title: CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.
    5. T helper cells with captured peptide-MHC-II (H2-Ab1) antigen molecules become effector cells that manifest better recall responses, and regulatory (Treg) cells with captured ligands exhibit enhanced suppression activity.
      Title: Presentation of acquired peptide-MHC class II ligands by CD4+ regulatory T cells or helper cells differentially regulates antigen-specific CD4+ T cell response.
    6. Data demonstrate that the presence of distinct forms of MHC-II with plasma membrane lipid rafts is required for MHC-II aggregation in APCs.
      Title: Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
    7. deletion of IA-2 and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system
      Title: Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.
    8. Phogrin and IA-2 function as essential regulators of autocrine insulin action in pancreatic beta-cells.
      Title: Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.
    9. The microenvironment of I-Ab molecules that acquired their antigenic cargo in endosomes may be important for polarized tubulation of class II-positive compartments in antigen-presenting dendritic cells.
      Title: Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells.
    10. crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution
      Title: Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histocompatibility 2, class II antigen A, beta 1
    Names
    H-2 class II histocompatibility antigen, A beta chain
    MHC class II H2-IA-beta-psi
    histocompatibility 2, class II antigen A, beta, promoter 1
    major histocompatibility complex class II beta chain
    response to metastatic cancers 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207105.3 → NP_996988.2  histocompatibility 2, class II antigen A, beta 1 precursor

      See identical proteins and their annotated locations for NP_996988.2

      Status: VALIDATED

      Source sequence(s)
      AK077436, BB056841, BY205244, CK330363
      Consensus CDS
      CCDS37583.1
      UniProtKB/Swiss-Prot
      P14483
      UniProtKB/TrEMBL
      Q3TD53, Q8BPA0
      Related
      ENSMUSP00000041008.6, ENSMUST00000040828.7
      Conserved Domains (2) summary
      cd05766
      Location:125 → 218
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:40 → 111
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34482201..34488392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01921.1 GenPept UniProtKB/Swiss-Prot:P01921
    P06342.1 GenPept UniProtKB/Swiss-Prot:P06342
    P06343.1 GenPept UniProtKB/Swiss-Prot:P06343
    P06345.1 GenPept UniProtKB/Swiss-Prot:P06345
    P06346.1 GenPept UniProtKB/Swiss-Prot:P06346
    P14483.1 GenPept UniProtKB/Swiss-Prot:P14483

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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