Inpp5k inositol polyphosphate 5-phosphatase K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inpp5kprovided by MGI
Official Full Name: inositol polyphosphate 5-phosphatase Kprovided by MGI
Primary source: MGI:MGI:1194899
See related: Ensembl:ENSMUSG00000006127 AllianceGenome:MGI:1194899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C62; Pps; SKIP
Summary: Enables inositol bisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and vasopressin receptor activity. Involved in several processes, including cellular response to cAMP; negative regulation of metabolic process; and negative regulation of signal transduction. Acts upstream of or within in utero embryonic development and response to insulin. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 44.4), thymus adult (RPKM 36.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75519893..75539691)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75629067..75648865)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma.
Title: Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma.
findings underscore the specific and prominent role of SKIP and GRP78 in the regulation of insulin-dependent PI 3-kinase signaling in skeletal muscle
Title: Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78.
prominent role of SKIP in the development of insulin resistance in skeletal muscle
Title: Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.
the physiological role of Pak1-SKIP binding is in the regulation of insulin signaling in skeletal muscle
Title: Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain.
SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis.
Title: Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1.
Title: Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Title: Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts.
Title: The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Title: Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
These results imply that SKIP regulates insulin signaling in skeletal muscle.
Title: Increased insulin action in SKIP heterozygous knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol bisphosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol bisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables inositol bisphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol trisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol trisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables inositol trisphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate 5-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol trisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol trisphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vasopressin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycogen (starch) synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of renal water transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of urine volume	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info	PubMed
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inositol polyphosphate 5-phosphatase K

Names: PI-5-phosphatase related; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; putative PI-5-phosphatase; skeletal muscle and kidney enriched inositol polyphosphate phosphatase; skeletal muscle and kidney-enriched inositol phosphatase

NP_032942.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

XP_006532570.1

EC 3.1.3.36

EC 3.1.3.56

EC 3.1.3.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008916.2 → NP_032942.1 inositol polyphosphate 5-phosphatase K

See identical proteins and their annotated locations for NP_032942.1

Status: VALIDATED

Source sequence(s)

BC066112

Consensus CDS

CCDS25053.1

UniProtKB/Swiss-Prot

O09040, Q8C5L6

UniProtKB/TrEMBL

Q05DI2, Q5ND43

Related

ENSMUSP00000006286.3, ENSMUST00000006286.9

Conserved Domains (2) summary

pfam17751
Location:350 → 450

SKICH; SKICH domain

cl00490
Location:32 → 339

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

75519893..75539691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532507.4 → XP_006532570.1 inositol polyphosphate 5-phosphatase K isoform X1

UniProtKB/TrEMBL

Q05DI2

Conserved Domains (2) summary

pfam17751
Location:350 → 454

SKICH; SKICH domain

cl00490
Location:32 → 339

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily