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    Nt5c 5',3'-nucleotidase, cytosolic [ Mus musculus (house mouse) ]

    Gene ID: 50773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5cprovided by MGI
    Official Full Name
    5',3'-nucleotidase, cytosolicprovided by MGI
    Primary source
    MGI:MGI:1354954
    See related
    Ensembl:ENSMUSG00000020736 AllianceGenome:MGI:1354954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnt; Dnt1; Umph2; Umph-2
    Summary
    Enables IMP 5'-nucleotidase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleoside monophosphate catabolic process. Acts upstream of or within deoxyribonucleotide catabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 50.2), colon adult (RPKM 41.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nt5c in Genome Data Viewer
    Location:
    11 E2; 11 80.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115381251..115382659, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115490420..115492070, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 80 Neighboring gene microRNA 3968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115323680-115323881 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324075-115324262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115324966-115325149 Neighboring gene predicted gene 11695 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E5298 Neighboring gene armadillo repeat containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115353318-115353427 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115374372-115374555 Neighboring gene STARR-positive B cell enhancer ABC_E470 Neighboring gene small ubiquitin-like modifier 2 Neighboring gene STARR-positive B cell enhancer ABC_E4015

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Provisional assignment of the gene for uridine monophosphatase-2 (Umph-2) to mouse chromosome 11. Wilson DE, et al. Biochem Genet, 1987 Feb. PMID 3034234
    2. Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Swallow DM, et al. Ann Hum Genet, 1983 Jan. PMID 6301357
    3. [Preliminary localization of TK1 and UMPH2 genes on swine chromosome 12]. Astakhova NM, et al. Genetika, 1994 Jun. PMID 7958795
    4. Characterization of pig-mink cell hybrids: assignment of the TK1 and UMPH2 genes to pig chromosome 12. Zhdanova NS, et al. Mamm Genome, 1994 Dec. PMID 7894159
    5. Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check? Vogel S, et al. J Biol Chem, 2012 Mar 16. PMID 22277657, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in allantoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dCMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dUMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within deoxyribonucleotide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    5'(3')-deoxyribonucleotidase, cytosolic type
    Names
    5' nucleotidase, deoxy (pyrimidine), cytosolic type C
    cytosolic 5',3'-pyrimidine nucleotidase
    dNT-1
    deoxy-5'-nucleotidase 1
    uridine monophosphatase 2
    NP_001404571.1
    NP_001404572.1
    NP_056622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417642.1 → NP_001404571.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645470

    2. NM_001417643.1 → NP_001404572.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645470
      UniProtKB/TrEMBL
      A2A9X5
      Related
      ENSMUSP00000102140.2, ENSMUST00000106530.8

    3. NM_015807.2 → NP_056622.1  5'(3')-deoxyribonucleotidase, cytosolic type isoform 1

      See identical proteins and their annotated locations for NP_056622.1

      Status: VALIDATED

      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS25637.1
      UniProtKB/Swiss-Prot
      Q9JM14
      Related
      ENSMUSP00000021082.7, ENSMUST00000021082.7
      Conserved Domains (1) summary
      cl21460
      Location:5 → 196
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_184549.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645470

    2. NR_184550.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645470

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115381251..115382659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JM14.1 GenPept UniProtKB/Swiss-Prot:Q9JM14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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