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    Bag5 BCL2-associated athanogene 5 [ Mus musculus (house mouse) ]

    Gene ID: 70369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bag5provided by MGI
    Official Full Name
    BCL2-associated athanogene 5provided by MGI
    Primary source
    MGI:MGI:1917619
    See related
    Ensembl:ENSMUSG00000049792 AllianceGenome:MGI:1917619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bag-5; 1600025G07Rik; 4930405J06Rik
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity; enzyme binding activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including negative regulation of protein metabolic process; negative regulation of protein refolding; and protein stabilization. Part of junctional membrane complex. Used to study dilated cardiomyopathy 2F. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2F. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 180.4), CNS E11.5 (RPKM 14.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bag5 in Genome Data Viewer
    Location:
    12 F1; 12 61.11 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111675922..111679690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111709488..111713256, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bag5 protects neuronal cells from amyloid β-induced cell death. Guo K, et al. J Mol Neurosci, 2015 Apr. PMID 25367796
    2. A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia. Wongong R, et al. Sci Rep, 2024 May 25. PMID 38796549, Free PMC Article
    3. BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. Gan S, et al. EMBO Rep, 2024 Apr. PMID 38454159, Free PMC Article
    4. Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. Bracho-Valdés I, et al. Int J Mol Sci, 2023 Dec 15. PMID 38139359, Free PMC Article
    5. Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. Hakui H, et al. Sci Transl Med, 2022 Jan 19. PMID 35044787

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia.
      Title: A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia.
    2. BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.
      Title: BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.
    3. Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
      Title: Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
    4. knockdown of Bag5 exacerbated Abeta1-42-induced apoptosis.
      Title: Bag5 protects neuronal cells from amyloid β-induced cell death.
    5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.
      Title: BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.
    6. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death.
      Title: BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inclusion body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inclusion body assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of junctional membrane complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BAG family molecular chaperone regulator 5
    Names
    BAG-family molecular chaperone regulator-5 (BAG-5)
    bcl-2-associated athanogene 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324480.1 → NP_001311409.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AC152065, AK160246, BC055762, CJ046703
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q3TVA8, Q8CI32, Q8K175, Q9DAU0
      Related
      ENSMUSP00000125183.2, ENSMUST00000160576.2
      Conserved Domains (1) summary
      smart00264
      Location:9 → 86
      BAG; BAG domains, present in regulator of Hsp70 proteins

    2. NM_001324481.1 → NP_001311410.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AK160246, BC055762, CJ046703
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q3TVA8, Q8CI32, Q8K175, Q9DAU0
      Conserved Domains (1) summary
      smart00264
      Location:9 → 86
      BAG; BAG domains, present in regulator of Hsp70 proteins

    3. NM_001324482.1 → NP_001311411.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AC152065, AK160246, BC055762, CJ047026
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q3TVA8, Q8CI32, Q8K175, Q9DAU0
      Conserved Domains (1) summary
      smart00264
      Location:9 → 86
      BAG; BAG domains, present in regulator of Hsp70 proteins

    4. NM_027404.2 → NP_081680.1  BAG family molecular chaperone regulator 5

      See identical proteins and their annotated locations for NP_081680.1

      Status: VALIDATED

      Source sequence(s)
      AC152065, BC055762, CX243791
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q3TVA8, Q8CI32, Q8K175, Q9DAU0
      Related
      ENSMUSP00000051049.7, ENSMUST00000054636.7
      Conserved Domains (1) summary
      smart00264
      Location:9 → 86
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111675922..111679690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516217.5 → XP_006516280.1  BAG family molecular chaperone regulator 5 isoform X1

      See identical proteins and their annotated locations for XP_006516280.1

      UniProtKB/Swiss-Prot
      Q3TVA8, Q8CI32, Q8K175, Q9DAU0
      Conserved Domains (1) summary
      smart00264
      Location:9 → 86
      BAG; BAG domains, present in regulator of Hsp70 proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI32.1 GenPept UniProtKB/Swiss-Prot:Q8CI32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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