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    Paqr3 progestin and adipoQ receptor family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305203, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Paqr3provided by RGD
    Official Full Name
    progestin and adipoQ receptor family member 3provided by RGD
    Primary source
    RGD:1310426
    See related
    EnsemblRapid:ENSRNOG00000002035 AllianceGenome:RGD:1310426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in positive regulation of SREBP signaling pathway and positive regulation of cholesterol biosynthetic process. Predicted to act upstream of or within negative regulation of neuron projection development; negative regulation of protein phosphorylation; and protein localization to Golgi apparatus. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 60.8), Spleen (RPKM 54.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paqr3 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (12766539..12796461)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12462568..12484999)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14107513..14129780)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 like 5 Neighboring gene U6 spliceosomal RNA Neighboring gene BMP-2 inducible kinase Neighboring gene uncharacterized LOC134481718 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation. Qiu J, et al. Diabetes Res Clin Pract, 2021 Oct. PMID 34461141
    2. Spatial regulation of Raf kinase signaling by RKTG. Feng L, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17724343, Free PMC Article
    3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation.
      Title: Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    progestin and adipoQ receptor family member 3
    Names
    progestin and adipoQ receptor family member III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012033.2 → NP_001012033.1  progestin and adipoQ receptor family member 3

      See identical proteins and their annotated locations for NP_001012033.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K658, A6K659, F7ELC3, Q6AXP7
      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    2. NM_001428777.1 → NP_001415706.1  progestin and adipoQ receptor family member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K658, A6K659, F7ELC3, Q6AXP7

    3. NM_001428779.1 → NP_001415708.1  progestin and adipoQ receptor family member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K658, A6K659, F7ELC3, Q6AXP7

    4. NM_001428781.1 → NP_001415710.1  progestin and adipoQ receptor family member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K658, A6K659, F7ELC3, Q6AXP7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      12766539..12796461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599171.3 → XP_017454660.1  progestin and adipoQ receptor family member 3 isoform X1

      Related
      ENSRNOP00000037290.4, ENSRNOT00000032130.6
      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    2. XM_017599170.3 → XP_017454659.1  progestin and adipoQ receptor family member 3 isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    3. XM_039091840.2 → XP_038947768.1  progestin and adipoQ receptor family member 3 isoform X2

      Conserved Domains (1) summary
      cl03831
      Location:4 → 193
      HlyIII; Haemolysin-III related

    4. XM_039091841.2 → XP_038947769.1  progestin and adipoQ receptor family member 3 isoform X2

      Conserved Domains (1) summary
      cl03831
      Location:4 → 193
      HlyIII; Haemolysin-III related

    RNA

    1. XR_010057364.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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