Odad3 outer dynein arm docking complex subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odad3provided by MGI
Official Full Name: outer dynein arm docking complex subunit 3provided by MGI
Primary source: MGI:MGI:1924859
See related: Ensembl:ENSMUSG00000039632 AllianceGenome:MGI:1924859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc151; b2b1885Clo; C330001K17Rik
Summary: Involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and seminiferous tubule development. Located in centriole and ciliary basal body. Is active in sperm flagellum. Is expressed in node; testis; and trachea. Used to study Kartagener syndrome and primary ciliary dyskinesia 30. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 15.6), CNS E18 (RPKM 2.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 8.01 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21901167..21914268, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21989871..22002972, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ccdc151 gene deletion in adult animals results in abnormal sperm counts and defective sperm motility.
Title: Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia.
Ccdc151 expression is strongly induced during in vitro differentiation of motile cilia of ependymal cells.
Title: The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals.
C330001K17Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outer dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary rootlet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary tip	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm docking complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sperm flagellum	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: outer dynein arm-docking complex subunit 3

Names: coiled-coil domain containing 151; coiled-coil domain-containing protein 151

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163787.1 → NP_001157259.1 outer dynein arm-docking complex subunit 3 isoform 1

See identical proteins and their annotated locations for NP_001157259.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC163623, AK021166, BC057069

Consensus CDS

CCDS52740.1

UniProtKB/TrEMBL

A0A0R4J1K3

Related

ENSMUSP00000110993.3, ENSMUST00000115336.10

Conserved Domains (1) summary

COG1196
Location:64 → 437

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_029939.3 → NP_084215.2 outer dynein arm-docking complex subunit 3 isoform 2

See identical proteins and their annotated locations for NP_084215.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AC163623, AK031175, BC057069

Consensus CDS

CCDS22917.1

UniProtKB/Swiss-Prot

G3X951, Q6PGE8, Q8BSN3, Q9CWC6

Related

ENSMUSP00000041117.6, ENSMUST00000044926.6

Conserved Domains (1) summary

COG1196
Location:64 → 436

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

21901167..21914268 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242626.1 → XP_011240928.1 outer dynein arm-docking complex subunit 3 isoform X2

Conserved Domains (1) summary

COG1196
Location:79 → 451

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_011242625.1 → XP_011240927.1 outer dynein arm-docking complex subunit 3 isoform X1

Conserved Domains (1) summary

COG1196
Location:79 → 452

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006510685.2 → XP_006510748.1 outer dynein arm-docking complex subunit 3 isoform X3

See identical proteins and their annotated locations for XP_006510748.1

UniProtKB/TrEMBL

A0A0R4J1K3

Conserved Domains (1) summary

COG1196
Location:64 → 437

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006510687.3 → XP_006510750.1 outer dynein arm-docking complex subunit 3 isoform X4

Conserved Domains (1) summary

TIGR02168
Location:3 → 257

SMC_prok_B; chromosome segregation protein SMC, common bacterial type