Slc22a20 solute carrier family 22 (organic anion transporter), member 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a20provided by MGI
Official Full Name: solute carrier family 22 (organic anion transporter), member 20provided by MGI
Primary source: MGI:MGI:2685809
See related: Ensembl:ENSMUSG00000037451 AllianceGenome:MGI:2685809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm963; mOAT6; OAT1-L
Summary: Predicted to be involved in organic anion transport. Predicted to be located in membrane. Is expressed in embryo; nasal cavity mucosa; and testis. Orthologous to human SLC22A20P (solute carrier family 22 member 20, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6020262..6036171, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5970234..5986143, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression in Sertoli cells suggests Oat6 may be an important determinant of blood-testis barrier function
Title: Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles.
Oat1, Oat3, and Oat6 function largely in organic anion transport but also bind and transport organic cations.
Title: Interaction of organic cations with organic anion transporters.
despite sharing close overall sequence homology, Oat1, Oat3, and Oat6 have signficantly different binding pockets
Title: Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.
the substrate binding preferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the more broadly expressed transporter, Oat1
Title: Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
These data demonstrate for the first time that the novel murine gene Oat6 (Slc22a20) encodes a functional organic anion transporter and mOat6 is indeed the newest member of the OAT gene family.
Title: Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).
Oat6 might play a direct or indirect role in olfaction, such as modulation of the availability of odorant organic anions at the mucosal surface.
Title: Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

Gm963 (e-PCR), detects polymorphism
- UniSTS:463362

Slc22a20 (e-PCR), detects polymorphism
- UniSTS:547022

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic anion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 20

Names: OAT1-like organic anion transporter; SLC22 organic anion transporter; organic anion transporter 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198650.2 → NP_941052.1 solute carrier family 22 member 20

See identical proteins and their annotated locations for NP_941052.1

Status: PROVISIONAL

Source sequence(s)

AC131692

Consensus CDS

CCDS29486.1

UniProtKB/Swiss-Prot

Q5JBT1, Q80UJ1

Related

ENSMUSP00000049473.8, ENSMUST00000041827.8

Conserved Domains (2) summary

cd06174
Location:138 → 507

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 518

2A0119; cation transport protein