Podxl podocalyxin-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Podxlprovided by MGI
Official Full Name: podocalyxin-likeprovided by MGI
Primary source: MGI:MGI:1351317
See related: Ensembl:ENSMUSG00000025608 AllianceGenome:MGI:1351317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC; Ly102; Pclp1; PCLP-1; Podxl1
Summary: Involved in several processes, including negative regulation of cell-cell adhesion; regulation of microvillus assembly; and regulation of synapse assembly. Acts upstream of or within leukocyte migration. Located in apical plasma membrane and microvillus membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including genitourinary system; integumental system; intraembryonic coelom; nervous system; and sensory organ. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 100.7), kidney adult (RPKM 59.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.57 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (31496428..31540872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (31519493..31563937, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in micedagger.
Title: Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in mice†.
Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease.
Title: Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease.
The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Title: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
Title: Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.
Podxl-KO led to heightened G-CSF activation of Rap1a(GTP), and Rap1a(GTP) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a activation during stress hematopoiesis.
Title: Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2.
Title: High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2.
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Title: The cell surface mucin podocalyxin regulates collective breast tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin signaling
Title: Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via β-catenin signaling.
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
Title: Podocalyxin regulates murine lung vascular permeability by altering endothelial cell adhesion.
CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway.
Title: [Connective tissue growth factor mediates high glucose-induced down-regulation of podocalyxin expression in mouse podocytes].

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AW121214 (e-PCR)
- UniSTS:165457

Podxl (e-PCR), detects polymorphism
- UniSTS:527498

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial tube formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microvillus assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microvillus assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in microvillus membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in slit diaphragm	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: podocalyxin

Names: podocalyxin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013723.3 → NP_038751.2 podocalyxin precursor

See identical proteins and their annotated locations for NP_038751.2

Status: VALIDATED

Source sequence(s)

AF290209, BY137094

Consensus CDS

CCDS19983.1

UniProtKB/Swiss-Prot

Q9ESZ1, Q9R0M4

UniProtKB/TrEMBL

Q791G4, Q8VIQ4

Related

ENSMUSP00000026698.8, ENSMUST00000026698.8

Conserved Domains (2) summary

pfam05109
Location:27 → 295

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam06365
Location:301 → 502

CD34_antigen; CD34/Podocalyxin family