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    Prl3d2 prolactin family 3, subfamily d, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 215028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prl3d2provided by MGI
    Official Full Name
    prolactin family 3, subfamily d, member 1provided by MGI
    Primary source
    MGI:MGI:2660935
    See related
    Ensembl:ENSMUSG00000062737 AllianceGenome:MGI:2660935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd5; Plib; PL-Ib
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 11.5) See more
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    Genomic context

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    See Prl3d2 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27305678..27311538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27121695..27127555)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin Neighboring gene prolactin family 3, subfamily d, member 1 Neighboring gene prolactin family 3, subfamily d, member 3 Neighboring gene prolactin family 3, subfamily c, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer. Hu D, et al. Dev Biol, 2013 Oct 15. PMID 23911935
    2. Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway. Matsuura K, et al. Nat Commun, 2011 Nov 22. PMID 22109522
    3. Murine transcription factor Math6 is a regulator of placenta development. Böing M, et al. Sci Rep, 2018 Oct 9. PMID 30301918, Free PMC Article
    4. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
    5. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin family 3, subfamily d, member 1
    Names
    PL-1 beta
    growth hormone d5
    placental lactogen-I beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384087.1 → NP_001371016.1  prolactin family 3, subfamily d, member 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL589679, LM644172
      UniProtKB/TrEMBL
      F6R3P9, Q8CGZ6
      Related
      ENSMUSP00000130458.4, ENSMUST00000164964.4
      Conserved Domains (1) summary
      cd10288
      Location:25 → 224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    2. NM_172155.2 → NP_742167.1  prolactin family 3, subfamily d, member 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_742167.1

      Status: VALIDATED

      Source sequence(s)
      AA111428, BC064735
      Consensus CDS
      CCDS49222.1
      UniProtKB/TrEMBL
      Q5SZY7, Q8CGZ6, Q8CGZ8
      Related
      ENSMUSP00000079579.6, ENSMUST00000080755.12
      Conserved Domains (1) summary
      cd10288
      Location:24 → 223
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27305678..27311538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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