Zfand5 zinc finger, AN1-type domain 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfand5provided by MGI
Official Full Name: zinc finger, AN1-type domain 5provided by MGI
Primary source: MGI:MGI:1278334
See related: Ensembl:ENSMUSG00000024750 AllianceGenome:MGI:1278334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Za20d2; Zfp216; 2310057A04Rik; 5830475F03Rik
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including face development; fibroblast migration; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ZFAND5 (zinc finger AN1-type containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 34.4), ovary adult (RPKM 17.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 14.32 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (21249150..21264204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (21271786..21286840)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Title: Molecular mechanism for activation of the 26S proteasome by ZFAND5.
Unlike other proteasome regulators, ZFAND5 enhances multiple 26S activities and overall cellular protein breakdown.
Title: ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation.
Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRNA binding.
Title: The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions.
ZNF216 functions in protein degradation via the UPS and plays a crucial role in muscle atrophy.
Title: A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy.
ZNF216 is a potent inhibitory factor for osteoclast differentiation and the mechanism is unlikely due to direct attenuation of the NF-kappa B pathway
Title: A RANKL-inducible gene Znf216 in osteoclast differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124463 (e-PCR)
- UniSTS:161285

BE107775 (e-PCR)
- UniSTS:247051

NoName (e-PCR)
- UniSTS:491289

MARC_26819-26820:1034280769:3 (e-PCR)
- UniSTS:269087

D9S1986 (e-PCR)
- UniSTS:87

AU021721 (e-PCR)
- UniSTS:180611

Zfand5 (e-PCR), detects polymorphism
- UniSTS:507336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within face development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AN1-type zinc finger protein 5

Names: zinc finger A20 domain-containing protein 2; zinc finger protein 216; zinc finger, A20 domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.