CPK21 calcium-dependent protein kinase 21 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CPK21
Official Full Name: calcium-dependent protein kinase 21
Primary source: TAIR:AT4G04720
Locus tag: AT4G04720
See related: Araport:AT4G04720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCPK21; calcium-dependent protein kinase 21; T4B21.13; T4B21_13
Summary: member of Calcium Dependent Protein Kinase
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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Calcium-dependent protein kinases CPK21 and CPK23 phosphorylate and activate the iron-regulated transporter IRT1 to regulate iron deficiency in Arabidopsis.
Title: Calcium-dependent protein kinases CPK21 and CPK23 phosphorylate and activate the iron-regulated transporter IRT1 to regulate iron deficiency in Arabidopsis.
Plasma membrane-associated calcium signaling modulates cadmium transport.
Title: Plasma membrane-associated calcium signaling modulates cadmium transport.
Ca(2+)-dependent phosphorylation of NRAMP1 by CPK21 and CPK23 facilitates manganese uptake and homeostasis in Arabidopsis.
Title: Ca(2+)-dependent phosphorylation of NRAMP1 by CPK21 and CPK23 facilitates manganese uptake and homeostasis in Arabidopsis.
results show that GORK can be phosphorylated by CPK21 and suggest that 14-3-3 proteins control GORK activity through binding with and activation of CPK21.
Title: The Arabidopsis GORK K(+)-channel is phosphorylated by calcium-dependent protein kinase 21 (CPK21), which in turn is activated by 14-3-3 proteins.
Redox regulation of AtCPK21 by Trx-h1 in Arabidopsis thaliana in response to external stimuli is important for appropriate cellular responses.
Title: Thioredoxin h regulates calcium dependent protein kinases in plasma membranes.
Loss-of-function seedlings of cpk21 are more tolerant to hyperosmotic stress.
Title: Calcium-dependent protein kinase CPK21 functions in abiotic stress response in Arabidopsis thaliana.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_001340500.1

NM_116710.3

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

NP_001319867.1

calcium-dependent protein kinase 21 (CPK21); FUNCTIONS IN: in 6 functions; INVOLVED IN: protein amino acid phosphorylation, N-terminal protein myristoylation; LOCATED IN: plasma membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 15 (TAIR:AT4G21940.1); Has 137194 Blast hits to 129287 proteins in 3977 species: Archae - 168; Bacteria - 14125; Metazoa - 50898; Fungi - 18038; Plants - 29874; Viruses - 499; Other Eukaryotes - 23592 (source: NCBI BLink).

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