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    Prrg3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) [ Mus musculus (house mouse) ]

    Gene ID: 208748, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrg3provided by MGI
    Official Full Name
    proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)provided by MGI
    Primary source
    MGI:MGI:2685214
    See related
    Ensembl:ENSMUSG00000033361 AllianceGenome:MGI:2685214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm368
    Summary
    This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in genital fat pad adult (RPKM 45.8), lung adult (RPKM 10.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrg3 in Genome Data Viewer
    Location:
    X A7.3; X 37.15 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71005769..71016328)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71962164..71972722)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) Neighboring gene PAS domain containing repressor 1 Neighboring gene fetal and adult testis expressed 1 Neighboring gene cyclic nucleotide gated channel alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. Kulman JD, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11171957, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 3
    Names
    proline-rich Gla protein 3
    proline-rich gamma-carboxyglutamic acid protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081135.3 → NP_001074604.1  transmembrane gamma-carboxyglutamic acid protein 3 precursor

      See identical proteins and their annotated locations for NP_001074604.1

      Status: VALIDATED

      Source sequence(s)
      AL731693
      Consensus CDS
      CCDS41001.1
      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Related
      ENSMUSP00000038947.7, ENSMUST00000048790.7
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    2. NM_001303028.2 → NP_001289957.1  transmembrane gamma-carboxyglutamic acid protein 3 precursor

      See identical proteins and their annotated locations for NP_001289957.1

      Status: VALIDATED

      Source sequence(s)
      AL731693
      Consensus CDS
      CCDS41001.1
      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Related
      ENSMUSP00000128073.2, ENSMUST00000170096.8
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      71005769..71016328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527925.5 → XP_006527988.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006527988.1

      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    2. XM_006527927.5 → XP_006527990.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006527990.1

      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    3. XM_006527924.5 → XP_006527987.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006527987.1

      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

    4. XM_006527926.4 → XP_006527989.1  transmembrane gamma-carboxyglutamic acid protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006527989.1

      UniProtKB/Swiss-Prot
      A3KGD9, B2RPV1, Q6PAQ9
      Conserved Domains (1) summary
      pfam00594
      Location:24 → 63
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PAQ9.2 GenPept UniProtKB/Swiss-Prot:Q6PAQ9

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