Eif2s2 eukaryotic translation initiation factor 2 subunit 2 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif2s2provided by MGI
Official Full Name: eukaryotic translation initiation factor 2 subunit 2 betaprovided by MGI
Primary source: MGI:MGI:1914454
See related: Ensembl:ENSMUSG00000074656 AllianceGenome:MGI:1914454
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EIF2; 38kDa; EIF2B; D2Ertd303e; 2810026E11Rik
Summary: Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Acts upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Is active in synapse. Is expressed in several structures, including blastocyst; colon; early embryo; gonad; and liver. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 37.7), placenta adult (RPKM 37.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 76.89 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (154713330..154734826, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (154871410..154892906, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provides evidence that even a mild mutation in eIF2B, leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs.
Title: Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
GCN2 activation increased phosphorylation of its substrate eIF2alpha and the induction of the integrated stress response master regulator, ATF4.
Title: Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4
Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2.
Title: Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124251 (e-PCR)
- UniSTS:161073

MHAa59g8.seq (e-PCR)
- UniSTS:125239

AW822225 (e-PCR)
- UniSTS:207431

RH126926 (e-PCR)
- UniSTS:207432

AA986487 (e-PCR)
- UniSTS:159057

NoName (e-PCR)
- UniSTS:234577

RH126828 (e-PCR)
- UniSTS:167310

RH125809 (e-PCR)
- UniSTS:162555

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 2 subunit 2

Names: eIF-2-beta; eIF2-beta; eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.