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    Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11765, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ap1g1provided by MGI
    Official Full Name
    adaptor protein complex AP-1, gamma 1 subunitprovided by MGI
    Primary source
    MGI:MGI:101919
    See related
    Ensembl:ENSMUSG00000031731 AllianceGenome:MGI:101919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adtg; D8Ertd374e
    Summary
    Predicted to enable several functions, including GTP-dependent protein binding activity; clathrin adaptor activity; and kinesin binding activity. Predicted to be involved in Golgi to lysosome transport; endosome to melanosome transport; and positive regulation of natural killer cell degranulation. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Located in perinuclear region of cytoplasm and trans-Golgi network. Is active in presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap1g1 in Genome Data Viewer
    Location:
    8 D3; 8 57.26 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110505215..110590842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109778583..109864210)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112261750-112261859 Neighboring gene STARR-seq mESC enhancer starr_22658 Neighboring gene ataxin 1-like Neighboring gene STARR-seq mESC enhancer starr_22659 Neighboring gene STARR-seq mESC enhancer starr_22660 Neighboring gene predicted gene, 51550 Neighboring gene La ribonucleoprotein domain family, member 1B pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112302310-112302493 Neighboring gene STARR-seq mESC enhancer starr_22661 Neighboring gene predicted gene, 17344 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene predicted gene, 25321 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene STARR-seq mESC enhancer starr_22662 Neighboring gene STARR-positive B cell enhancer ABC_E6682 Neighboring gene STARR-positive B cell enhancer ABC_E6683 Neighboring gene STARR-positive B cell enhancer ABC_E10522 Neighboring gene STARR-positive B cell enhancer ABC_E8263 Neighboring gene MARVEL (membrane-associating) domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. Robinson MS. J Cell Biol, 1990 Dec. PMID 2126014, Free PMC Article
    2. Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis. Lefkir Y, et al. Mol Biol Cell, 2004 Feb. PMID 14617812, Free PMC Article
    3. A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Johnson KR, et al. Mamm Genome, 2016 Jun. PMID 27090238, Free PMC Article
    4. Early embryonic death of mice deficient in gamma-adaptin. Zizioli D, et al. J Biol Chem, 1999 Feb 26. PMID 10026148
    5. Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Kent HM, et al. Structure, 2002 Aug. PMID 12176391

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ap1g1 (fgt) mutant mice provide a new animal model to study the in vivo roles of gamma-1 adaptin and the AP-1 complex throughout development and to investigate factors that underlie its associated phenotypic abnormalities
      Title: A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.
    2. 1.8 A resolution structure and binding site for Eps15 and gamma-synergin is presented
      Title: Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basolateral protein secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endosome to melanosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in melanosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet dense granule organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-1 complex subunit gamma-1
    Names
    adapter-related protein complex 1 subunit gamma-1
    adaptor protein complex AP-1 subunit gamma-1
    adaptor-related protein complex 1 subunit gamma-1
    clathrin assembly protein complex 1 gamma-1 large chain
    gamma-adaptin
    gamma1-adaptin
    golgi adaptor HA1/AP1 adaptin subunit gamma-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301211.1 → NP_001288140.1  AP-1 complex subunit gamma-1 isoform 2

      See identical proteins and their annotated locations for NP_001288140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC122807, BU755831, BY738987, X54424
      Consensus CDS
      CCDS80929.1
      UniProtKB/Swiss-Prot
      P22892
      UniProtKB/TrEMBL
      Q3UKX8
      Related
      ENSMUSP00000034171.9, ENSMUST00000034171.9
      Conserved Domains (4) summary
      smart00809
      Location:709 → 817
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam05109
      Location:590 → 702
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:142 → 163
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:23 → 574
      Adaptin_N; Adaptin N terminal region

    2. NM_009677.6 → NP_033807.2  AP-1 complex subunit gamma-1 isoform 1

      See identical proteins and their annotated locations for NP_033807.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122807, AK036387, BU755831, BY738987
      Consensus CDS
      CCDS40475.1
      UniProtKB/TrEMBL
      Q3UKX8, Q8CBB7
      Related
      ENSMUSP00000090844.7, ENSMUST00000093157.13
      Conserved Domains (4) summary
      smart00809
      Location:712 → 820
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam05109
      Location:593 → 705
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00044
      Location:142 → 163
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:23 → 577
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110505215..110590842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22892.3 GenPept UniProtKB/Swiss-Prot:P22892

    Gene LinkOut

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