Nlrp4e NLR family, pyrin domain containing 4E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp4eprovided by MGI
Official Full Name: NLR family, pyrin domain containing 4Eprovided by MGI
Primary source: MGI:MGI:3056600
See related: Ensembl:ENSMUSG00000045693 AllianceGenome:MGI:3056600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nlrp4; Nalp4e; Nalp-epsilon; 4930406H16Rik
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to be active in cytoplasm. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A3; 7 10.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (23000617..23061702)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (23301192..23362277)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
Title: NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
Title: USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.
suggest that Hmgb1-IL-23-IL-17-IL-6-Stat3 axis plays a pivotal role in tumor development in murine models of melanoma
Title: Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice.
that Nlrp4e, a maternal-zygotic-effect gene, may not be involved in oocyte maturation but may play a critical role in early embryogenesis.
Title: Developmental expression and possible functional roles of mouse Nlrp4e in preimplantation embryos.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

AA960620 (e-PCR)
- UniSTS:160514

Krt8 (e-PCR), detects polymorphism
- UniSTS:502649

Krt2-8 (e-PCR), detects polymorphism
- UniSTS:143746

RH136318 (e-PCR)
- UniSTS:210309

Krt8 (e-PCR), detects polymorphism
- UniSTS:499095

RH125425 (e-PCR)
- UniSTS:162247

Nlrp4a (e-PCR), detects polymorphism
- UniSTS:526825

Krt8 (e-PCR), detects polymorphism
- UniSTS:499181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 4E

Names: NACHT, leucine rich repeat and PYD containing 4E; NALP, epsilon; NLR family, pyrin domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004194.2 → NP_001004194.2 NACHT, LRR and PYD domains-containing protein 4E

See identical proteins and their annotated locations for NP_001004194.2

Status: VALIDATED

Source sequence(s)

AC150900

Consensus CDS

CCDS20928.1

UniProtKB/Swiss-Prot

Q66X19

UniProtKB/TrEMBL

B9EIC2

Related

ENSMUSP00000075794.4, ENSMUST00000076470.5

Conserved Domains (5) summary

COG4886
Location:742 → 929

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:681 → 960

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 92

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00034
Location:666 → 691

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:148 → 316

NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

23000617..23061702

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242760.1 → XP_030098620.1 NACHT, LRR and PYD domains-containing protein 4E isoform X1

Conserved Domains (4) summary

cd08320
Location:10 → 93

Pyrin_NALPs; Pyrin death domain found in NALP proteins

pfam05729
Location:161 → 329

NACHT; NACHT domain

pfam17776
Location:464 → 577

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:406 → 462

NOD2_WH; NOD2 winged helix domain