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    Cyp2j12 cytochrome P450, family 2, subfamily j, polypeptide 12 [ Mus musculus (house mouse) ]

    Gene ID: 242546, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp2j12provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 12provided by MGI
    Primary source
    MGI:MGI:3717097
    See related
    Ensembl:ENSMUSG00000081225 AllianceGenome:MGI:3717097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp2j12-ps
    Summary
    Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.5), cortex adult (RPKM 1.1) and 1 other tissue See more
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    Genomic context

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    See Cyp2j12 in Genome Data Viewer
    Location:
    4 C5; 4 44.28 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95987553..96029389, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96099316..96141152, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene hook microtubule tethering protein 1 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_10818 Neighboring gene STARR-seq mESC enhancer starr_10819 Neighboring gene STARR-seq mESC enhancer starr_10820 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 7 Neighboring gene cytochrome P450, family 2, subfamily j, member 15, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 11,12-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate 14,15-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linoleic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100182.2 → NP_001093652.1  cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL772395
      Consensus CDS
      CCDS57287.1
      UniProtKB/TrEMBL
      G3UXT0
      Related
      ENSMUSP00000133811.2, ENSMUST00000097972.5
      Conserved Domains (1) summary
      pfam00067
      Location:44 → 497
      p450; Cytochrome P450

    2. NM_001355721.1 → NP_001342650.1  cytochrome P450, family 2, subfamily j, polypeptide 12, pseudogene isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK136922, AL772395
      Conserved Domains (1) summary
      pfam00067
      Location:1 → 355
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      95987553..96029389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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