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    Hpcal4 hippocalcin-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 170638, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hpcal4provided by MGI
    Official Full Name
    hippocalcin-like 4provided by MGI
    Primary source
    MGI:MGI:2157521
    See related
    Ensembl:ENSMUSG00000046093 AllianceGenome:MGI:2157521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NVP-2
    Summary
    Predicted to enable calcium channel regulator activity; calcium ion binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in central nervous system; male reproductive gland or organ; and tongue. Orthologous to human HPCAL4 (hippocalcin like 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 155.7), cortex adult (RPKM 149.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Hpcal4 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123077297..123088492)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123183504..123194699)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 8b Neighboring gene predicted gene, 17244 Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene STARR-positive B cell enhancer ABC_E8988 Neighboring gene peptidylprolyl isomerase E (cyclophilin E) Neighboring gene STARR-seq mESC enhancer starr_11286 Neighboring gene STARR-positive B cell enhancer ABC_E10256 Neighboring gene 5'-nucleotidase, cytosolic IA Neighboring gene hairy/enhancer-of-split related with YRPW motif-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential transcriptional expression of Ca2+ BP superfamilies in murine gastrointestinal smooth muscles. Ohya S, et al. Am J Physiol Gastrointest Liver Physiol, 2002 Dec. PMID 12388203
    2. Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing. Alvaro CG, et al. PLoS One, 2020. PMID 32015563, Free PMC Article
    3. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Onishi M, et al. Genomics, 2004 Apr. PMID 15028287
    4. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that the neural calcium sensor Hpcal4 likely makes a limited contribution to pain and itch processing.
      Title: Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hippocalcin-like protein 4
    Names
    neural visinin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429858.1 → NP_001416787.1  hippocalcin-like protein 4

      Status: VALIDATED

      Source sequence(s)
      AL606934
      UniProtKB/Swiss-Prot
      Q8BGZ1
      UniProtKB/TrEMBL
      B2RRY8

    2. NM_001429859.1 → NP_001416788.1  hippocalcin-like protein 4

      Status: VALIDATED

      Source sequence(s)
      AL606934
      UniProtKB/Swiss-Prot
      Q8BGZ1
      UniProtKB/TrEMBL
      B2RRY8

    3. NM_174998.5 → NP_778163.1  hippocalcin-like protein 4

      See identical proteins and their annotated locations for NP_778163.1

      Status: VALIDATED

      Source sequence(s)
      AL606934
      Consensus CDS
      CCDS18611.1
      UniProtKB/Swiss-Prot
      Q8BGZ1
      UniProtKB/TrEMBL
      B2RRY8, F2Z3Z1
      Related
      ENSMUSP00000051487.3, ENSMUST00000059667.9
      Conserved Domains (1) summary
      COG5126
      Location:13 → 181
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123077297..123088492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGZ1.3 GenPept UniProtKB/Swiss-Prot:Q8BGZ1

    Gene LinkOut

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