Ifit3 interferon-induced protein with tetratricopeptide repeats 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifit3provided by MGI
Official Full Name: interferon-induced protein with tetratricopeptide repeats 3provided by MGI
Primary source: MGI:MGI:1101055
See related: Ensembl:ENSMUSG00000074896 AllianceGenome:MGI:1101055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P49; Ifi49
Summary: Predicted to enable identical protein binding activity. Involved in response to stilbenoid. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Is expressed in alimentary system; eye; face; liver; and nervous system. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 9.6), liver E18 (RPKM 8.0) and 17 other tissues See more
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Genomic context

Location:: 19 C1; 19 29.74 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34560519..34566382)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34583119..34588982)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice.
Title: IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice.
Knockdown of IFIT3 ameliorates multiple sclerosis via selectively regulating M1 polarization of microglia in an experimental autoimmune encephalomyelitis model.
Title: Knockdown of IFIT3 ameliorates multiple sclerosis via selectively regulating M1 polarization of microglia in an experimental autoimmune encephalomyelitis model.
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Title: Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function.
Title: Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function.
Murine Ifit3 restricts the replication of Rabies virus both in vitro and in vivo.
Title: Murine Ifit3 restricts the replication of Rabies virus both in vitro and in vivo.
Expression of interferon-induced protein with tetratricopeptide repeats 3 (Ifit3) is decreased in CD4-Positive T-Lymphocytes from Systemic Lupus Erythematosus-prone mice following TOFA and DEXA treatment.
Title: JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation.
Ifitm3 restricts West Nile virus pathogenesis likely through multiple mechanisms, including the direct control of infection in subsets of cells.
Title: The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.
the mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.
Title: Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.
Expression increased significantly during LCMV and WNV infection, being widespread and localized predominantly to common as well as distinct neuronal populations in the brain.
Title: Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifit3 (e-PCR), detects polymorphism
- UniSTS:506994

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 3

Names: GARG-49; IFIT-3; IRG2; glucocorticoid-attenuated response gene 49 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010501.2 → NP_034631.1 interferon-induced protein with tetratricopeptide repeats 3

See identical proteins and their annotated locations for NP_034631.1

Status: VALIDATED

Source sequence(s)

AK153226

Consensus CDS

CCDS29762.1

UniProtKB/Swiss-Prot

Q64345, Q99L62

UniProtKB/TrEMBL

Q4FJY6, Q5FW82

Related

ENSMUSP00000099889.4, ENSMUST00000102825.4

Conserved Domains (3) summary

COG5010
Location:136 → 272

TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]

sd00006
Location:136 → 164

TPR; TPR repeat [structural motif]

pfam13424
Location:48 → 126

TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34560519..34566382

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247153.2 → XP_011245455.1 interferon-induced protein with tetratricopeptide repeats 3 isoform X2

UniProtKB/TrEMBL

Q4FJY6

Conserved Domains (3) summary

TIGR02917
Location:81 → 325

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:161 → 189

TPR; TPR repeat [structural motif]

pfam13424
Location:76 → 151

TPR_12; Tetratricopeptide repeat
XM_011247151.3 → XP_011245453.1 interferon-induced protein with tetratricopeptide repeats 3 isoform X1

See identical proteins and their annotated locations for XP_011245453.1

UniProtKB/TrEMBL

Q4FJY6

Conserved Domains (3) summary

TIGR02917
Location:87 → 331

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:167 → 195

TPR; TPR repeat [structural motif]

pfam13424
Location:82 → 157

TPR_12; Tetratricopeptide repeat
XM_036161448.1 → XP_036017341.1 interferon-induced protein with tetratricopeptide repeats 3 isoform X3

UniProtKB/TrEMBL

Q4FJY6

Conserved Domains (3) summary

TIGR02917
Location:64 → 308

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:144 → 172

TPR; TPR repeat [structural motif]

pfam13424
Location:59 → 134

TPR_12; Tetratricopeptide repeat