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    Gucy1b2 guanylate cyclase 1, soluble, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 239134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gucy1b2provided by MGI
    Official Full Name
    guanylate cyclase 1, soluble, beta 2provided by MGI
    Primary source
    MGI:MGI:2660873
    See related
    Ensembl:ENSMUSG00000021933 AllianceGenome:MGI:2660873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GC-SB2; B930025B03
    Summary
    Predicted to enable guanylate cyclase activity and nitric oxide binding activity. Predicted to be involved in cGMP-mediated signaling and response to oxygen levels. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in spinal cord. Orthologous to human GUCY1B2 (guanylate cyclase 1 soluble subunit beta 2 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Gucy1b2 in Genome Data Viewer
    Location:
    14 D1; 14 33.21 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (62610384..62693745, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62372935..62456291, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene STARR-seq mESC enhancer starr_36897 Neighboring gene predicted gene, 41173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:62961404-62961513 Neighboring gene ribonuclease H2, subunit B Neighboring gene STARR-positive B cell enhancer ABC_E11572 Neighboring gene STARR-seq mESC enhancer starr_36900 Neighboring gene predicted gene, 46457 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:63044104-63044321 Neighboring gene predicted gene, 35468 Neighboring gene STARR-seq mESC enhancer starr_36901 Neighboring gene predicted gene, 41172 Neighboring gene predicted gene 4131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2. Omura M, et al. Mol Cell Neurosci, 2015 Mar. PMID 25701815, Free PMC Article
    2. A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. Bleymehl K, et al. Neuron, 2016 Dec 21. PMID 27916458, Free PMC Article
    3. Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. Duranski MR, et al. Am J Physiol Heart Circ Physiol, 2006 Dec. PMID 16877550
    4. Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes. Wang H, et al. J Mol Cell Cardiol, 2009 Aug. PMID 19345227, Free PMC Article
    5. Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Koike K, et al. Neuron, 2021 Aug 4. PMID 34186026

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low oxygen induces calcium influx in a subpopulation of olfactory epithelium neurons, and Gucy1b2 and Trpc2 are required for these responses.
      Title: A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.
    2. Gucy1b2 is a marker for type B cells in olfactory epithelium.
      Title: Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2.
    3. These data suggests a novel physiological role for PDE5 in restricting the effects of NOS3/sGC/PKG signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC]
      Title: Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.
    4. These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways.
      Title: Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitric oxide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxygen levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of guanylate cyclase complex, soluble IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate cyclase soluble subunit beta-2
    Names
    soluble guanylyl cyclase beta2 subunit
    NP_001191269.1
    NP_766398.1
    XP_006519048.2
    XP_006519050.1
    XP_006519051.1
    XP_011243363.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204340.1 → NP_001191269.1  guanylate cyclase soluble subunit beta-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC129219, AC154805
      Consensus CDS
      CCDS56962.1
      UniProtKB/TrEMBL
      B2RQD5, E9Q6H0
      Related
      ENSMUSP00000128114.2, ENSMUST00000165651.8
      Conserved Domains (4) summary
      smart00044
      Location:498 → 688
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:525 → 707
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:83 → 244
      HNOB; Haem-NO-binding
      pfam07701
      Location:333 → 519
      HNOBA; Heme NO binding associated

    2. NM_172810.3 → NP_766398.1  guanylate cyclase soluble subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_766398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK047129, BY391897
      Consensus CDS
      CCDS27190.1
      UniProtKB/TrEMBL
      B2RQD5, Q8BXH3
      Related
      ENSMUSP00000022501.4, ENSMUST00000022501.10
      Conserved Domains (4) summary
      smart00044
      Location:513 → 703
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:540 → 722
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:83 → 244
      HNOB; Haem-NO-binding
      pfam07701
      Location:348 → 534
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      62610384..62693745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245061.4 → XP_011243363.2  guanylate cyclase soluble subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      B2RQD5
      Conserved Domains (3) summary
      pfam00211
      Location:572 → 754
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:115 → 276
      HNOB; Haem-NO-binding
      pfam07701
      Location:380 → 566
      HNOBA; Heme NO binding associated

    2. XM_006518987.4 → XP_006519050.1  guanylate cyclase soluble subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      Q6XE41
      Conserved Domains (3) summary
      pfam00211
      Location:459 → 641
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:267 → 453
      HNOBA; Heme NO binding associated
      pfam07700
      Location:2 → 163
      HNOB; Haem-NO-binding

    3. XM_006518988.2 → XP_006519051.1  guanylate cyclase soluble subunit beta-2 isoform X4

      UniProtKB/TrEMBL
      Q6XE41
      Conserved Domains (3) summary
      pfam00211
      Location:424 → 606
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07701
      Location:232 → 418
      HNOBA; Heme NO binding associated
      pfam07700
      Location:1 → 128
      HNOB; Haem-NO-binding

    4. XM_006518985.5 → XP_006519048.2  guanylate cyclase soluble subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      B2RQD5
      Conserved Domains (3) summary
      pfam00211
      Location:572 → 754
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam07700
      Location:115 → 276
      HNOB; Haem-NO-binding
      pfam07701
      Location:380 → 566
      HNOBA; Heme NO binding associated
    Nucleotide Protein Strain
    Heading Accession and Version

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