Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldh3a2provided by MGI
Official Full Name: aldehyde dehydrogenase family 3, subfamily A2provided by MGI
Primary source: MGI:MGI:1353452
See related: Ensembl:ENSMUSG00000010025 AllianceGenome:MGI:1353452
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ahd3; Ahd-3; Aldh4; FALDH; Ahd-3r; Ahd3-r; Aldh4-r
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including hexadecanal metabolic process; nervous system development; and terpenoid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver adult (RPKM 28.8), liver E18 (RPKM 13.6) and 28 other tissues See more
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61114240..61158267, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61223417..61267528, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome.
Title: Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome.
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Title: Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
Title: Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
FALDH has roles in insulin action and is deregulated in states associated with altered insulin signaling
Title: Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aldh3a2 (e-PCR), detects polymorphism
- UniSTS:461951

Aldh3a2 (e-PCR), detects polymorphism
- UniSTS:527247

RH140634 (e-PCR)
- UniSTS:222703

U14390 (e-PCR)
- UniSTS:180220

AI194803 (e-PCR)
- UniSTS:180221

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty aldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain-alcohol oxidase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aldehyde metabolic process	IC Inferred by Curator more info	PubMed
involved_in aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in formaldehyde metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hexadecanal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hexadecanal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in phytol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in sesquiterpenoid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldehyde dehydrogenase family 3 member A2

Names: alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3; aldehyde dehydrogenase 4, liver microsomal (class 3) regulator; fatty aldehyde dehydrogenase variant form

NP_001318043.1

EC 1.2.1.3

EC 1.2.1.94

NP_001318044.1

EC 1.2.1.3

EC 1.2.1.94

NP_001404235.1

EC 1.2.1.3

EC 1.2.1.94

NP_031463.2

EC 1.2.1.3

EC 1.2.1.94

XP_006532093.1

EC 1.2.1.3

EC 1.2.1.94

XP_006532094.1

EC 1.2.1.3

EC 1.2.1.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331114.2 → NP_001318043.1 aldehyde dehydrogenase family 3 member A2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL672172

UniProtKB/TrEMBL

Q99PH4

Conserved Domains (1) summary

cd07132
Location:5 → 444

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
NM_001331115.2 → NP_001318044.1 aldehyde dehydrogenase family 3 member A2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.

Source sequence(s)

AL672172

UniProtKB/TrEMBL

Q99PH4

Conserved Domains (1) summary

cl11961
Location:1 → 374

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
NM_001417306.1 → NP_001404235.1 aldehyde dehydrogenase family 3 member A2 isoform 4

Status: VALIDATED

Source sequence(s)

AL672172
NM_007437.6 → NP_031463.2 aldehyde dehydrogenase family 3 member A2 isoform 2

See identical proteins and their annotated locations for NP_031463.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate internal exon resulting in a frameshift, and differs in the 3' UTR. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL672172

Consensus CDS

CCDS24809.1

UniProtKB/Swiss-Prot

P47740, Q99L64

UniProtKB/TrEMBL

Q3U7B5, Q8C3C9

Related

ENSMUSP00000073764.8, ENSMUST00000074127.14

Conserved Domains (1) summary

cd07132
Location:5 → 444

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RNA

NR_138545.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL646093, AL672172

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61114240..61158267 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532031.5 → XP_006532094.1 aldehyde dehydrogenase family 3 member A2 isoform X2

UniProtKB/TrEMBL

Q3U7B5, Q8C3C9

Conserved Domains (1) summary

cd07132
Location:5 → 444

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
XM_006532030.5 → XP_006532093.1 aldehyde dehydrogenase family 3 member A2 isoform X1

UniProtKB/TrEMBL

B1AV77, Q8BQ93

Related

ENSMUSP00000104355.3, ENSMUST00000108715.3

Conserved Domains (1) summary

cd07132
Location:5 → 444

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins