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    Gprc5c G protein-coupled receptor, family C, group 5, member C [ Mus musculus (house mouse) ]

    Gene ID: 70355, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gprc5cprovided by MGI
    Official Full Name
    G protein-coupled receptor, family C, group 5, member Cprovided by MGI
    Primary source
    MGI:MGI:1917605
    See related
    Ensembl:ENSMUSG00000051043 AllianceGenome:MGI:1917605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Raig3; 1110028I06Rik; 3200002M13Rik
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and visual perception. Located in mitochondrion. Is expressed in several structures, including embryo endoderm; liver; metanephros; spleen; and testis. Orthologous to human GPRC5C (G protein-coupled receptor class C group 5 member C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 60.6), genital fat pad adult (RPKM 25.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gprc5c in Genome Data Viewer
    Location:
    11 E2; 11 80.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114741976..114763443)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114851150..114872617)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 19A Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:114734569-114734722 Neighboring gene STARR-seq mESC enhancer starr_31138 Neighboring gene CD300A molecule Neighboring gene CD300 molecule like family member B Neighboring gene predicted gene 11699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response. Kawabata Y, et al. FEBS Lett, 2023 Aug. PMID 37418589
    2. Identifying the localization and exploring a functional role for Gprc5c in the kidney. Rajkumar P, et al. FASEB J, 2018 Apr. PMID 29196502, Free PMC Article
    3. GPRC5C regulates the composition of cilia in the olfactory system. Bhat S, et al. BMC Biol, 2023 Dec 18. PMID 38110903, Free PMC Article
    4. G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals. Dashti P, et al. Bone, 2023 Nov. PMID 37558192, Free PMC Article
    5. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Amisten S, et al. Endocr J, 2017 Mar 31. PMID 28228611

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRC5C regulates the composition of cilia in the olfactory system.
      Title: GPRC5C regulates the composition of cilia in the olfactory system.
    2. G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.
      Title: G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.
    3. The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response.
      Title: The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response.
    4. Gprc5c KO mice have altered acid-base homeostasis and reduced NHE3 activity in the kidney.
      Title: Identifying the localization and exploring a functional role for Gprc5c in the kidney.
    5. Data suggest that agents (such as all-trans retinoic acid) that activate Gprc5c restore and/or maintain functional insulin-secreting cells; Gprc5c appears to play role in regulation of expression of genes controlling apoptosis, cell survival, and cell proliferation in insulin-secreting cells.
      Title: Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.
    6. GPRC5C does not affect behavior, though it has a high sequence similarity to GPRC5B.
      Title: Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6786, MGC11976

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sevenless binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member C
    Names
    RAIG-3
    retinoic acid inducible protein 3
    retinoic acid-induced gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110337.1 → NP_001103807.1  G-protein coupled receptor family C group 5 member C isoform a precursor

      See identical proteins and their annotated locations for NP_001103807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK128950, AW536310, BY003041, BY108149, CO425185
      Consensus CDS
      CCDS48978.1
      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      I7HPW4
      Related
      ENSMUSP00000061760.6, ENSMUST00000053361.12
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    2. NM_001110338.1 → NP_001103808.1  G-protein coupled receptor family C group 5 member C isoform b precursor

      See identical proteins and their annotated locations for NP_001103808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK003946, AK128950, AL669969, BI134748
      Consensus CDS
      CCDS25612.1
      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      J3JS84
      Related
      ENSMUSP00000136702.2, ENSMUST00000177952.8
      Conserved Domains (1) summary
      pfam00003
      Location:91 → 144
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    3. NM_147217.3 → NP_671750.2  G-protein coupled receptor family C group 5 member C isoform b precursor

      See identical proteins and their annotated locations for NP_671750.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK003946, AK128950, BB871704, BI134748
      Consensus CDS
      CCDS25612.1
      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      J3JS84
      Related
      ENSMUSP00000021071.8, ENSMUST00000021071.14
      Conserved Domains (1) summary
      pfam00003
      Location:91 → 144
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114741976..114763443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534164.4 → XP_006534227.1  G-protein coupled receptor family C group 5 member C isoform X2

      See identical proteins and their annotated locations for XP_006534227.1

      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      I7HPW4
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    2. XM_030246296.2 → XP_030102156.2  G-protein coupled receptor family C group 5 member C isoform X1

      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      Conserved Domains (1) summary
      cd15277
      Location:80 → 337
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    3. XM_006534163.4 → XP_006534226.1  G-protein coupled receptor family C group 5 member C isoform X2

      See identical proteins and their annotated locations for XP_006534226.1

      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      I7HPW4
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    4. XM_006534162.1 → XP_006534225.1  G-protein coupled receptor family C group 5 member C isoform X2

      See identical proteins and their annotated locations for XP_006534225.1

      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      I7HPW4
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

    5. XM_006534161.5 → XP_006534224.1  G-protein coupled receptor family C group 5 member C isoform X2

      See identical proteins and their annotated locations for XP_006534224.1

      UniProtKB/Swiss-Prot
      Q8K0H0, Q8K3J9
      UniProtKB/TrEMBL
      I7HPW4
      Conserved Domains (1) summary
      cd15277
      Location:47 → 304
      7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3J9.2 GenPept UniProtKB/Swiss-Prot:Q8K3J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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