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    Drc3 dynein regulatory complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 74665, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Drc3provided by MGI
    Official Full Name
    dynein regulatory complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1921915
    See related
    Ensembl:ENSMUSG00000056598 AllianceGenome:MGI:1921915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    m6Bei; Lrrc48; 4930449E07Rik
    Summary
    Located in sperm flagellum. Is expressed in brain; inner ear; lung epithelium; nasal cavity epithelium; and spinal cord ventricular layer. Orthologous to human DRC3 (dynein regulatory complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 20.8), ovary adult (RPKM 4.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Drc3 in Genome Data Viewer
    Location:
    11 B2; 11 37.81 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60243063..60285168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60352881..60394342)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene target of myb1-like 2 (chicken) Neighboring gene predicted gene, 38501 Neighboring gene STARR-seq mESC enhancer starr_29644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60147838-60148039 Neighboring gene STARR-positive B cell enhancer ABC_E77 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_29650 Neighboring gene STARR-positive B cell enhancer ABC_E1139 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_29653 Neighboring gene GID complex subunit 4, VID24 homolog Neighboring gene STARR-seq mESC enhancer starr_29654 Neighboring gene predicted gene 12268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice. Zhou S, et al. Signal Transduct Target Ther, 2023 Jan 10. PMID 36627292, Free PMC Article
    2. Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice. Ha S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261005, Free PMC Article
    3. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, et al. PLoS Genet, 2020 Jan. PMID 31961863, Free PMC Article
    4. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
    5. A forward genetic screen in mice identifies mutants with abnormal cortical patterning. Ha S, et al. Cereb Cortex, 2015 Jan. PMID 23968836, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice.
      Title: DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice.
    2. Mutations in Lrrc48 cause hydrocephalus, laterality defects, and sinusitis.
      Title: Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein regulatory complex subunit 3
    Names
    leucine rich repeat containing 48
    leucine-rich repeat-containing protein 48
    novel Leucine Rich Repeat domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029044.2 → NP_083320.1  dynein regulatory complex subunit 3

      See identical proteins and their annotated locations for NP_083320.1

      Status: PROVISIONAL

      Source sequence(s)
      AK015430
      Consensus CDS
      CCDS36172.1
      UniProtKB/Swiss-Prot
      Q9D5E4
      Related
      ENSMUSP00000104363.3, ENSMUST00000108723.9
      Conserved Domains (2) summary
      sd00031
      Location:67 → 88
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:53 → 200
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60243063..60285168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157053.1 → XP_036012946.1  dynein regulatory complex subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9D5E4
      Conserved Domains (2) summary
      sd00031
      Location:67 → 88
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:53 → 200
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_006534382.5 → XP_006534445.1  dynein regulatory complex subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam14580
      Location:7 → 56
      LRR_9; Leucine-rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5E4.1 GenPept UniProtKB/Swiss-Prot:Q9D5E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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