Plpp2 phospholipid phosphatase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plpp2provided by MGI
Official Full Name: phospholipid phosphatase 2provided by MGI
Primary source: MGI:MGI:1354945
See related: Ensembl:ENSMUSG00000052151 AllianceGenome:MGI:1354945
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lpp2; PAP2c; PAP2-G; Ppap2c; PAP2-gamma
Summary: The protein encoded by this gene is a lipid phosphate phosphohydrolase. It is an integral membrane protein that catalyzes the conversion of phosphatidic acid to diacylglycerol and inorganic phosphate. The transcript is expressed at high levels in lung, liver, and kidney and at low levels in brain and heart. Null mutant mice are viable and fertile and display no overt phenotypic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Broad expression in large intestine adult (RPKM 123.4), small intestine adult (RPKM 120.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79362258..79369621, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79526424..79533787, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppap2c (e-PCR), detects polymorphism
- UniSTS:546962

D10Mit207 (e-PCR), detects polymorphism
- UniSTS:126107

D10Mit207.1 (e-PCR), detects polymorphism
- UniSTS:126108

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ceramide-1-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipid dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipid phosphatase 2

Names: lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2C

NP_001289318.1

EC 3.1.3.4

NP_001289319.1

EC 3.1.3.4

NP_001289371.1

EC 3.1.3.4

NP_056632.2

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302389.1 → NP_001289318.1 phospholipid phosphatase 2 isoform 2

See identical proteins and their annotated locations for NP_001289318.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).

Source sequence(s)

AK005452, AK049581, BB737982, BB868752, CA540403

Consensus CDS

CCDS78849.1

UniProtKB/TrEMBL

G3XA61

Related

ENSMUST00000163602.9

Conserved Domains (1) summary

cd03384
Location:38 → 183

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_001302390.1 → NP_001289319.1 phospholipid phosphatase 2 isoform 3

See identical proteins and their annotated locations for NP_001289319.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC100708, AK005452, AK049581, BB737982, BB868752, BQ571983

Consensus CDS

CCDS88047.1

UniProtKB/TrEMBL

A0A1W2P7I9

Related

ENSMUSP00000151683.2, ENSMUST00000218241.2

Conserved Domains (1) summary

cd03384
Location:1 → 121

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_001302442.1 → NP_001289371.1 phospholipid phosphatase 2 isoform 2

See identical proteins and their annotated locations for NP_001289371.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1. Both variants 2 and 4 encode the same protein (isoform 2).

Source sequence(s)

AK049581, BB737982, BB868752

Consensus CDS

CCDS78849.1

UniProtKB/TrEMBL

G3XA61

Related

ENSMUSP00000133247.2, ENSMUST00000166804.2

Conserved Domains (1) summary

cd03384
Location:38 → 183

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
NM_015817.3 → NP_056632.2 phospholipid phosphatase 2 isoform 1

See identical proteins and their annotated locations for NP_056632.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK049581, BB737982, BB868752

Consensus CDS

CCDS35966.1

UniProtKB/Swiss-Prot

Q9DAX2, Q9WUA4

UniProtKB/TrEMBL

Q5U4G4

Related

ENSMUSP00000069670.6, ENSMUST00000063879.13

Conserved Domains (1) summary

cd03384
Location:94 → 239

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...