Rdh9 retinol dehydrogenase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdh9provided by MGI
Official Full Name: retinol dehydrogenase 9provided by MGI
Primary source: MGI:MGI:2143528
See related: Ensembl:ENSMUSG00000056148 AllianceGenome:MGI:2143528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crad3
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in midbrain. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 20.2), large intestine adult (RPKM 14.5) and 4 other tissues See more
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Genomic context

Location:: 10 D3; 10 75.21 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127612274..127628566)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127776405..127792697)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

podocyte-specific overexpression of Rdh9 in established kidney disease due to either HIV-associated nephropathy or adriamycin-induced nephropathy decreases proteinuria, attenuates kidney injury, and restores podocyte differentiation markers
Title: Induction of retinol dehydrogenase 9 expression in podocytes attenuates kidney injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

AI121090 (e-PCR)
- UniSTS:160048

Rdh6 (e-PCR), detects polymorphism
- UniSTS:186538

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinol dehydrogenase 9

Names: cis-retinol/androgen dehydrogenase type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153133.2 → NP_694773.1 retinol dehydrogenase 9 precursor

See identical proteins and their annotated locations for NP_694773.1

Status: VALIDATED

Source sequence(s)

AC129576, AC131690

Consensus CDS

CCDS24251.1

UniProtKB/TrEMBL

E9Q9P8, Q8K5C8

Related

ENSMUSP00000057732.7, ENSMUST00000052652.7

Conserved Domains (2) summary

cd09805
Location:30 → 306

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:30 → 218

adh_short; short chain dehydrogenase