Evx1 even-skipped homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Evx1provided by MGI
Official Full Name: even-skipped homeobox 1provided by MGI
Primary source: MGI:MGI:95461
See related: Ensembl:ENSMUSG00000005503 AllianceGenome:MGI:95461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Evx-1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryo development; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and limb bud. Orthologous to human EVX1 (even-skipped homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 1.7), ovary adult (RPKM 1.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 25.44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (52290483..52295374)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (52313498..52318389)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evx1as has no function independent of EVX1, and is therefore unlikely to act in trans.
Title: The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

ECD13145 (e-PCR)
- UniSTS:294176

X54239 (e-PCR)
- UniSTS:125803

Evx1 (e-PCR), detects polymorphism
- UniSTS:143044

NoName (e-PCR)
- UniSTS:487635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord interneuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox even-skipped homolog protein 1

Names: even skipped homeotic gene 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007966.4 → NP_031992.1 homeobox even-skipped homolog protein 1

See identical proteins and their annotated locations for NP_031992.1

Status: VALIDATED

Source sequence(s)

AC113985

Consensus CDS

CCDS20149.1

UniProtKB/Swiss-Prot

P23683

Related

ENSMUSP00000031787.8, ENSMUST00000031787.8

Conserved Domains (1) summary

smart00389
Location:183 → 239

HOX; Homeodomain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

52290483..52295374

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505516.1 → XP_006505579.1 homeobox even-skipped homolog protein 1 isoform X1

Conserved Domains (1) summary

pfam00046
Location:5 → 58

Homeobox; Homeobox domain