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    Stra6l STRA6-like [ Mus musculus (house mouse) ]

    Gene ID: 74152, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stra6lprovided by MGI
    Official Full Name
    STRA6-likeprovided by MGI
    Primary source
    MGI:MGI:1921402
    See related
    Ensembl:ENSMUSG00000028327 AllianceGenome:MGI:1921402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbpr2; 1300002K09Rik
    Summary
    Predicted to enable retinol transmembrane transporter activity and signaling receptor activity. Acts upstream of or within establishment of localization in cell; retinol transport; and vitamin A import into cell. Located in plasma membrane. Is expressed in Harderian gland; genitourinary system; gut; and liver. Orthologous to human STRA6LP (STRA6 like, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 35.2), liver E18 (RPKM 4.8) and 2 other tissues See more
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    Genomic context

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    See Stra6l in Genome Data Viewer
    Location:
    4 B1; 4 24.39 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45818940..45887010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45824293..45887010)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10108 Neighboring gene STARR-seq mESC enhancer starr_10110 Neighboring gene predicted gene 12409 Neighboring gene aldehyde dehydrogenase 1 family, member B1 Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STARR-seq mESC enhancer starr_10113 Neighboring gene STARR-seq mESC enhancer starr_10114 Neighboring gene coiled-coil domain containing 180 Neighboring gene tudor domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function. Radhakrishnan R, et al. Nutrients, 2022 Jun 8. PMID 35745101, Free PMC Article
    2. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. Berry DC, et al. J Biol Chem, 2013 Aug 23. PMID 23839944, Free PMC Article
    3. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Alapatt P, et al. J Biol Chem, 2013 Jan 11. PMID 23105095, Free PMC Article
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.
      Title: Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC132877, MGC132878

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables retinol transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vitamin A import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vitamin A import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stimulated by retinoic acid gene 6 protein-like
    Names
    RBP4 receptor 2
    STRA6-like protein
    retinol-binding protein 4 receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305421.1 → NP_001292350.1  stimulated by retinoic acid gene 6 protein-like isoform 2

      See identical proteins and their annotated locations for NP_001292350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK004855, AK045033, AK050152, AL772381
      Consensus CDS
      CCDS80094.1
      UniProtKB/Swiss-Prot
      Q9DBN1
      Related
      ENSMUSP00000103411.2, ENSMUST00000107782.8
      Conserved Domains (1) summary
      pfam14752
      Location:1 → 511
      RBP_receptor; Retinol binding protein receptor

    2. NM_028788.4 → NP_083064.2  stimulated by retinoic acid gene 6 protein-like isoform 1

      See identical proteins and their annotated locations for NP_083064.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform.
      Source sequence(s)
      AK050152, AK050348, AL772381, BY776586
      Consensus CDS
      CCDS18141.1
      UniProtKB/Swiss-Prot
      B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
      Related
      ENSMUSP00000030011.6, ENSMUST00000030011.6
      Conserved Domains (1) summary
      pfam14752
      Location:14 → 602
      RBP_receptor; Retinol binding protein receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45818940..45887010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538310.5 → XP_006538373.1  stimulated by retinoic acid gene 6 protein-like isoform X1

      See identical proteins and their annotated locations for XP_006538373.1

      Conserved Domains (1) summary
      pfam14752
      Location:93 → 681
      RBP_receptor; Retinol binding protein receptor

    2. XM_036164494.1 → XP_036020387.1  stimulated by retinoic acid gene 6 protein-like isoform X2

      UniProtKB/Swiss-Prot
      B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
      Conserved Domains (1) summary
      pfam14752
      Location:14 → 602
      RBP_receptor; Retinol binding protein receptor

    3. XM_006538312.2 → XP_006538375.1  stimulated by retinoic acid gene 6 protein-like isoform X2

      See identical proteins and their annotated locations for XP_006538375.1

      UniProtKB/Swiss-Prot
      B1AWX8, Q14DP6, Q14DS9, Q8C7I6, Q9DBN1
      Related
      ENSMUSP00000103412.2, ENSMUST00000107783.8
      Conserved Domains (1) summary
      pfam14752
      Location:14 → 602
      RBP_receptor; Retinol binding protein receptor

    4. XM_006538311.3 → XP_006538374.1  stimulated by retinoic acid gene 6 protein-like isoform X1

      See identical proteins and their annotated locations for XP_006538374.1

      Conserved Domains (1) summary
      pfam14752
      Location:93 → 681
      RBP_receptor; Retinol binding protein receptor

    5. XM_006538313.2 → XP_006538376.1  stimulated by retinoic acid gene 6 protein-like isoform X3

      See identical proteins and their annotated locations for XP_006538376.1

      UniProtKB/Swiss-Prot
      Q9DBN1
      Conserved Domains (1) summary
      pfam14752
      Location:1 → 511
      RBP_receptor; Retinol binding protein receptor

    6. XM_006538315.2 → XP_006538378.1  stimulated by retinoic acid gene 6 protein-like isoform X3

      See identical proteins and their annotated locations for XP_006538378.1

      UniProtKB/Swiss-Prot
      Q9DBN1
      Conserved Domains (1) summary
      pfam14752
      Location:1 → 511
      RBP_receptor; Retinol binding protein receptor

    7. XM_006538314.3 → XP_006538377.1  stimulated by retinoic acid gene 6 protein-like isoform X3

      See identical proteins and their annotated locations for XP_006538377.1

      UniProtKB/Swiss-Prot
      Q9DBN1
      Conserved Domains (1) summary
      pfam14752
      Location:1 → 511
      RBP_receptor; Retinol binding protein receptor

    8. XM_006538317.4 → XP_006538380.1  stimulated by retinoic acid gene 6 protein-like isoform X4

      Conserved Domains (1) summary
      pfam14752
      Location:1 → 410
      RBP_receptor; Retinol binding protein receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBN1.1 GenPept UniProtKB/Swiss-Prot:Q9DBN1

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