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    Prn prion protein readthrough transcript [ Mus musculus (house mouse) ]

    Gene ID: 111368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prnprovided by MGI
    Official Full Name
    prion protein readthrough transcriptprovided by MGI
    Primary source
    MGI:MGI:97767
    See related
    Ensembl:ENSMUSG00000098754 AllianceGenome:MGI:97767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm28045; Gm44637; Prnp-Prnd
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring Prnp (major prion protein) and Prnd (prion-like protein doppel) genes on chromosome 2. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the presence of an in-frame, upstream AUG compared to the downstream gene. [provided by RefSeq, May 2013]
    Expression
    Broad expression in testis adult (RPKM 22.5), limb E14.5 (RPKM 10.9) and 17 other tissues See more
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    Genomic context

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    See Prn in Genome Data Viewer
    Location:
    2 F2; 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131751848..131798051)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131909928..131956131)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endogenous retroviral sequence 3 Neighboring gene laminin receptor 1 (ribosomal protein SA), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05721 Neighboring gene STARR-seq mESC enhancer starr_05722 Neighboring gene prion protein Neighboring gene STARR-seq mESC enhancer starr_05723 Neighboring gene prion like protein doppel Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Telling GC, et al. Proc Natl Acad Sci U S A, 1994 Oct 11. PMID 7937921, Free PMC Article
    2. Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. Hunter N, et al. J Gen Virol, 1992 Oct. PMID 1357080
    3. Prion proteins and ECTO-NOX proteins exhibit similar oscillating redox activities. Kim C, et al. Biochem Biophys Res Commun, 2004 Mar 19. PMID 14985132
    4. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Hsiao KK, et al. Proc Natl Acad Sci U S A, 1994 Sep 13. PMID 7916462, Free PMC Article
    5. Analysis of linkage between scrapie incubation period and the prion protein gene in mice. Race RE, et al. J Gen Virol, 1990 Feb. PMID 1968507

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein
      Title: Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Readthrough Prn

    Included genes: Prnp, Prnd

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prion protein gene complex
    Names
    Prnp-Prnd readthrough

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278258.1 → NP_001265187.1  prion protein gene complex

      See identical proteins and their annotated locations for NP_001265187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL833794
      UniProtKB/TrEMBL
      A0A075B668, A7U7N0, C7E3P5
      Related
      ENSMUSP00000122345.3, ENSMUST00000136783.2
      Conserved Domains (2) summary
      pfam00377
      Location:82 → 196
      Prion; Prion/Doppel alpha-helical domain
      pfam11466
      Location:19 → 48
      Doppel; Prion-like protein Doppel

    2. NM_001278259.1 → NP_001265188.1  prion protein gene complex

      See identical proteins and their annotated locations for NP_001265188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL833794
      UniProtKB/TrEMBL
      A0A075B668, A7U7N0, C7E3P5
      Related
      ENSMUSP00000116195.3, ENSMUST00000124100.8
      Conserved Domains (2) summary
      pfam00377
      Location:82 → 196
      Prion; Prion/Doppel alpha-helical domain
      pfam11466
      Location:19 → 48
      Doppel; Prion-like protein Doppel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131751848..131798051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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