Unc5cl unc-5 family C-terminal like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Unc5clprovided by MGI
Official Full Name: unc-5 family C-terminal likeprovided by MGI
Primary source: MGI:MGI:1923839
See related: Ensembl:ENSMUSG00000043592 AllianceGenome:MGI:1923839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zud; 2510009H09Rik
Summary: Predicted to enable peptidase activity. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Is expressed in central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human UNC5CL (unc-5 family C-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 18.8), small intestine adult (RPKM 18.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 24.14 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48761155..48846737)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48454127..48539709)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
Title: The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
Focuses on identification and characterization of human UNC5CL, but also identifies mouse Unc5cl.
Title: Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237661

BB155270 (e-PCR)
- UniSTS:186104

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UNC5C-like protein

Names: ZU5 and death domain-containing inhibitor of NF-kB; ZU5 and death domain-containing protein; protein unc-5 homolog C-like; unc-5 homolog C-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152823.4 → NP_690036.4 UNC5C-like protein

See identical proteins and their annotated locations for NP_690036.4

Status: VALIDATED

Source sequence(s)

AC165291

Consensus CDS

CCDS28870.1

UniProtKB/Swiss-Prot

Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8

UniProtKB/TrEMBL

E9QLC2

Related

ENSMUSP00000074159.7, ENSMUST00000074574.13

Conserved Domains (3) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain

cl14633
Location:408 → 488

DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48761155..48846737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317717.2 → XP_017173206.1 UNC5C-like protein isoform X2

UniProtKB/Swiss-Prot

Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8

Conserved Domains (3) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain

cl14633
Location:408 → 445

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006525099.4 → XP_006525162.1 UNC5C-like protein isoform X1

See identical proteins and their annotated locations for XP_006525162.1

UniProtKB/Swiss-Prot

Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8

UniProtKB/TrEMBL

E9QLC2

Conserved Domains (3) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain

cl14633
Location:408 → 488

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006525101.4 → XP_006525164.1 UNC5C-like protein isoform X3

UniProtKB/Swiss-Prot

Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8

Conserved Domains (3) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain

cl14633
Location:408 → 445

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006525102.4 → XP_006525165.1 UNC5C-like protein isoform X4

See identical proteins and their annotated locations for XP_006525165.1

Conserved Domains (2) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain
XM_006525104.4 → XP_006525167.1 UNC5C-like protein isoform X4

See identical proteins and their annotated locations for XP_006525167.1

Conserved Domains (2) summary

pfam00791
Location:108 → 185

ZU5; ZU5 domain

pfam17217
Location:243 → 346

UPA; UPA domain