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    Rgs22 regulator of G-protein signalling 22 [ Mus musculus (house mouse) ]

    Gene ID: 626596, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rgs22provided by MGI
    Official Full Name
    regulator of G-protein signalling 22provided by MGI
    Primary source
    MGI:MGI:3613651
    See related
    Ensembl:ENSMUSG00000037627 AllianceGenome:MGI:3613651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in brain; reproductive system; respiratory system; and submandibular gland. Orthologous to human RGS22 (regulator of G protein signaling 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 12.4) and lung adult (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Rgs22 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.46 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (35960664..36140718, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (35960508..36140572, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13B Neighboring gene predicted gene, 41292 Neighboring gene STARR-seq mESC enhancer starr_38348 Neighboring gene STARR-seq mESC enhancer starr_38349 Neighboring gene STARR-seq mESC enhancer starr_38350 Neighboring gene STARR-seq mESC enhancer starr_38351 Neighboring gene cytochrome c oxidase subunit 6C Neighboring gene STARR-seq mESC enhancer starr_38352 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene predicted gene, 22979 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K Neighboring gene sperm associated antigen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Hu Y, et al. Biol Reprod, 2008 Dec. PMID 18703424
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195748.1 → NP_001182677.1  regulator of G-protein signaling 22

      See identical proteins and their annotated locations for NP_001182677.1

      Status: VALIDATED

      Source sequence(s)
      AC121577, AC157521, AC166820
      Consensus CDS
      CCDS56979.1
      UniProtKB/Swiss-Prot
      G3UYX5
      Related
      ENSMUSP00000134259.2, ENSMUST00000172831.8
      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      35960664..36140718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245372.4 → XP_011243674.1  regulator of G-protein signaling 22 isoform X1

      See identical proteins and their annotated locations for XP_011243674.1

      UniProtKB/Swiss-Prot
      G3UYX5
      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_011245371.4 → XP_011243673.1  regulator of G-protein signaling 22 isoform X1

      See identical proteins and their annotated locations for XP_011243673.1

      UniProtKB/Swiss-Prot
      G3UYX5
      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_011245373.4 → XP_011243675.1  regulator of G-protein signaling 22 isoform X1

      See identical proteins and their annotated locations for XP_011243675.1

      UniProtKB/Swiss-Prot
      G3UYX5
      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_030248684.2 → XP_030104544.1  regulator of G-protein signaling 22 isoform X5

      Conserved Domains (2) summary
      cd08727
      Location:124 → 239
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:306 → 435
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. XM_011245370.4 → XP_011243672.1  regulator of G-protein signaling 22 isoform X1

      See identical proteins and their annotated locations for XP_011243672.1

      UniProtKB/Swiss-Prot
      G3UYX5
      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    6. XM_030248683.2 → XP_030104543.1  regulator of G-protein signaling 22 isoform X2

      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    7. XM_011245374.4 → XP_011243676.1  regulator of G-protein signaling 22 isoform X2

      Conserved Domains (4) summary
      cd08725
      Location:1019 → 1141
      RGS_RGS22_4; Regulator of G protein signaling domain RGS_RGS22_4
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:408 → 530
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    8. XM_036159533.1 → XP_036015426.1  regulator of G-protein signaling 22 isoform X3

      Conserved Domains (3) summary
      cd08726
      Location:846 → 975
      RGS_RGS22_3; Regulator of G protein signaling domain RGS_RGS22_3
      cd08727
      Location:664 → 779
      RGS_RGS22_2; Regulator of G protein signaling domain RGS_RGS22_2
      cl02565
      Location:1019 → 1116
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    9. XM_011245375.4 → XP_011243677.1  regulator of G-protein signaling 22 isoform X4

      Conserved Domains (1) summary
      cl02565
      Location:664 → 724
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3UYX5.1 GenPept UniProtKB/Swiss-Prot:G3UYX5

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