Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf19provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 19provided by MGI
Primary source: MGI:MGI:1352474
See related: Ensembl:ENSMUSG00000060548 AllianceGenome:MGI:1352474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAJ; Troy; TRADE; TAJ-ALPHA
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; integumental system; and respiratory system. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 14.8), CNS E11.5 (RPKM 12.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 32.06 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (61201283..61284304, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (60963834..61046855, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
Title: Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration.
Title: Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.
High TROY expression is associated with glioblastoma cell invasion.
Title: Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway.
TROY negatively modulates remyelination in the central nervous system.
Title: Inhibition of TROY promotes OPC differentiation and increases therapeutic efficacy of OPC graft for spinal cord injury.
the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation.
Title: TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.
TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.
Title: Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.
TROY is expressed in microglia, involved in their migration and targeted by propentofylline.
Title: Propentofylline targets TROY, a novel microglial signaling pathway.
functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways
Title: Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.
TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, and may play some roles in the developing and adult olfactory system
Title: TROY, a novel member of the tumor necrosis factor receptor superfamily in the central nervous system.
Troy protein is expressed in the matrix region of developing hair follicles and may have a subtle function in skin appendage development.
Title: Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237201

RH125405 (e-PCR)
- UniSTS:162227

AW123854 (e-PCR)
- UniSTS:180677

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair follicle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 19

Names: Toxicity and JNK inducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164155.1 → NP_001157627.1 tumor necrosis factor receptor superfamily member 19 precursor

See identical proteins and their annotated locations for NP_001157627.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK083283, BB526959, BB858206, BY637570, CB244999

Consensus CDS

CCDS36941.1

UniProtKB/Swiss-Prot

Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7

UniProtKB/TrEMBL

Q8BUM7

Related

ENSMUSP00000106867.3, ENSMUST00000111236.4

Conserved Domains (1) summary

cd13418
Location:33 → 149

TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
NM_013869.5 → NP_038897.4 tumor necrosis factor receptor superfamily member 19 precursor

See identical proteins and their annotated locations for NP_038897.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK028146, AK083283, BY637570, CF727607

Consensus CDS

CCDS36941.1

UniProtKB/Swiss-Prot

Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7

UniProtKB/TrEMBL

Q8BUM7

Related

ENSMUSP00000106865.3, ENSMUST00000111234.10

Conserved Domains (1) summary

cd13418
Location:33 → 149

TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

61201283..61284304 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158664.1 → XP_036014557.1 tumor necrosis factor receptor superfamily member 19 isoform X1

UniProtKB/TrEMBL

Q8BWR1

Conserved Domains (1) summary

cl22855
Location:1 → 17

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)