Tmed10 transmembrane p24 trafficking protein 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmed10provided by MGI
Official Full Name: transmembrane p24 trafficking protein 10provided by MGI
Primary source: MGI:MGI:1915831
See related: Ensembl:ENSMUSG00000021248 AllianceGenome:MGI:1915831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p23; Tmp21; p24delta1; 1110014C03Rik
Summary: Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including positive regulation of interleukin-1 production; positive regulation of protein secretion; and vesicle targeting, to, from or within Golgi. Acts upstream of or within negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. Located in zymogen granule membrane. Part of gamma-secretase complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 96.9), placenta adult (RPKM 58.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 39.65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (85387388..85421491, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (85340614..85374717, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis.
Title: Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis.
TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation.
Title: TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation.
Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway.
Title: Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway.
the C-terminal KKxxx Golgi-to-endoplasmic reticulum retrieval signal of TMED10 is required for gp40-mediated retention of class I.
Title: Cytomegalovirus gp40/m152 Uses TMED10 as ER Anchor to Retain MHC Class I.
This study provides an insight into the physiological function of TMP21 in the brain and pathological role of TMP21 in Alzheimer's disease.
Title: Regulation of global gene expression in brain by TMP21.
High levels of p23 expression are found in embryonic mouse brain, but the steady-state p23 levels gradually decline after birth to the lower adult level.
Title: Localization and regional distribution of p23/TMP21 in the brain.
These findings suggest that a fraction of p23 enters post-Golgi compartments and may function in the biogenesis and/or quality control of SGs.
Title: A subset of p23 localized on secretory granules in pancreatic beta-cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPI-coated vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in COPI-coated vesicle budding	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IDA Inferred from Direct Assay more info	PubMed
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cytosol to ERGIC protein transport	ISO Inferred from Sequence Orthology more info
involved_in cytosol to ERGIC protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to ERGIC	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ERGIC	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle targeting, to, from or within Golgi	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in COPI-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
part_of gamma-secretase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-secretase complex	ISO Inferred from Sequence Orthology more info
part_of gamma-secretase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane emp24 domain-containing protein 10

Names: 21 kDa transmembrane-trafficking protein; p24 family protein delta-1; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.