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    Mfsd2b MFSD2 lysolipid transporter B, sphingolipid [ Mus musculus (house mouse) ]

    Gene ID: 432628, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mfsd2bprovided by MGI
    Official Full Name
    MFSD2 lysolipid transporter B, sphingolipidprovided by MGI
    Primary source
    MGI:MGI:3583946
    See related
    Ensembl:ENSMUSG00000037336 AllianceGenome:MGI:3583946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1964
    Summary
    Enables sphingolipid transporter activity. Involved in lipid transport; positive regulation of platelet aggregation; and sphingosine-1-phosphate receptor signaling pathway. Is active in plasma membrane. Is expressed in liver lobe. Orthologous to human MFSD2B (MFSD2 lysolipid transporter B, sphingolipid). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 21.0), liver E14 (RPKM 17.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mfsd2b in Genome Data Viewer
    Location:
    12 A1.1; 12 2.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4912438..4924359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4862438..4874359, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4023 Neighboring gene FK506 binding protein 1b Neighboring gene WD repeat and coiled coil containing Neighboring gene UBX domain protein 2A Neighboring gene STARR-seq mESC enhancer starr_31460 Neighboring gene STARR-seq mESC enhancer starr_31462 Neighboring gene STARR-seq mESC enhancer starr_31463 Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_31464 Neighboring gene STARR-positive B cell enhancer ABC_E5317 Neighboring gene predicted gene, 23167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Mfsd2b impairs thrombotic functions of platelets. Chandrakanthan M, et al. Nat Commun, 2021 Apr 16. PMID 33863882, Free PMC Article
    2. Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases. Goto H, et al. J Biol Chem, 2021 Jan-Jun. PMID 33785361, Free PMC Article
    3. MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells. Kobayashi N, et al. Sci Rep, 2018 Mar 21. PMID 29563527, Free PMC Article
    4. Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells. Thomas N, et al. Nat Commun, 2023 Dec 14. PMID 38097610, Free PMC Article
    5. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Vu TM, et al. Nature, 2017 Oct 26. PMID 29045386

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction.
      Title: Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction.
    2. Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
      Title: Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
    3. Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.
      Title: Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.
    4. Deletion of Mfsd2b impairs thrombotic functions of platelets.
      Title: Deletion of Mfsd2b impairs thrombotic functions of platelets.
    5. Using microarray analysis of erythroid cell lines overexpressing human and mouse MFSD2B study showed sphingosine 1-phosphate (S1P) transport activity. The properties of S1P release by MFSD2B were similar to those in erythrocytes. Moreover, knockout of MFSD2B in MEDEP-E14 cells decreased S1P export from the cells. These results strongly suggest that MFSD2B is a novel S1P transporter in erythroid cells.
      Title: MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells.
    6. S1P secretion by Mfsd2b is critical for red blood cell morphology; data reveal an unexpected physiological role of red blood cells in sphingolipid metabolism in circulation; findings open new avenues for investigating the signalling roles of S1P derived from red blood cells and platelets
      Title: Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.
    7. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis.
      Title: Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sphingolipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingolipid transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingolipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sphingolipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingosine-1-phosphate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine-1-phosphate transporter MFSD2B
    Names
    mMfsd2b
    major facilitator superfamily domain containing 2B
    major facilitator superfamily domain-containing protein 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033488.2 → NP_001028660.2  sphingosine-1-phosphate transporter MFSD2B

      Status: VALIDATED

      Source sequence(s)
      CT571254
      Consensus CDS
      CCDS36401.2
      UniProtKB/Swiss-Prot
      Q3T9M1, Q3TRN2, Q3U198
      UniProtKB/TrEMBL
      B8JK43
      Related
      ENSMUSP00000045315.8, ENSMUST00000045921.14
      Conserved Domains (2) summary
      pfam13347
      Location:34 → 467
      MFS_2; MFS/sugar transport protein
      cl21472
      Location:26 → 467
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4912438..4924359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515146.2 → XP_006515209.1  sphingosine-1-phosphate transporter MFSD2B isoform X1

      UniProtKB/TrEMBL
      B8JK42
      Related
      ENSMUSP00000117057.2, ENSMUST00000137337.8
      Conserved Domains (1) summary
      cl28910
      Location:2 → 363
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T9M1.1 GenPept UniProtKB/Swiss-Prot:Q3T9M1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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