Slc25a10 solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a10provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10provided by MGI
Primary source: MGI:MGI:1353497
See related: Ensembl:ENSMUSG00000025792 AllianceGenome:MGI:1353497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dic
Summary: Enables malate transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in glyceraldehyde-3-phosphate biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in embryo and testis. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 83.0), kidney adult (RPKM 73.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120382663..120391987)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120491837..120501161)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import.
Title: MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury through Maintaining SLC25A10-Mediated Mitochondrial Glutathione Import.
identified a new protein-protein interaction mechanism in which CLOCK can directly regulate cell metabolism via the mitochondrial membrane transporter SLC25A10.
Title: The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10.
Slc25a10 plays an important role in supplying malate for citrate transport required for fatty acid synthesis and its inhibition might effectively reduce lipid accumulation in adipose tissues
Title: Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a10 (e-PCR), detects polymorphism
- UniSTS:508541

Slc25a10 (e-PCR), detects polymorphism
- UniSTS:547033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables dicarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables malate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables malate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables oxaloacetate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thiosulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in malate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in malate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in oxaloacetate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiosulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiosulfate transport	IEA Inferred from Electronic Annotation more info
involved_in thiosulfate transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial dicarboxylate carrier

Names: dicarboxylate ion carrier; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 10; solute carrier family 25 member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.