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    Adam11 a disintegrin and metallopeptidase domain 11 [ Mus musculus (house mouse) ]

    Gene ID: 11488, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Adam11provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 11provided by MGI
    Primary source
    MGI:MGI:1098667
    See related
    Ensembl:ENSMUSG00000020926 AllianceGenome:MGI:1098667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdc
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit defects in spatial learning, motor coordination and altered perception of pain. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
    Expression
    Broad expression in cerebellum adult (RPKM 47.6), cortex adult (RPKM 21.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adam11 in Genome Data Viewer
    Location:
    11 E1; 11 66.48 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102652261..102671089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102761413..102780263)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 43 Neighboring gene STARR-seq mESC enhancer starr_30819 Neighboring gene DBF4 zinc finger B Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 pseudogene Neighboring gene gap junction protein, gamma 1 Neighboring gene predicted gene, 22683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation and neuronal expression of the cellular disintegrin ADAM11 gene in mouse nervous system. Rybnikova E, et al. Neuroscience, 2002. PMID 12088751
    2. Altered nociceptive response in ADAM11-deficient mice. Takahashi E, et al. Brain Res, 2006 Jun 30. PMID 16729981
    3. Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice. Hauck SJ, et al. Horm Metab Res, 2002 Sep. PMID 12384824
    4. Deficits in spatial learning and motor coordination in ADAM11-deficient mice. Takahashi E, et al. BMC Neurosci, 2006 Feb 26. PMID 16504143, Free PMC Article
    5. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. Inoue D, et al. J Biol Chem, 1998 Feb 13. PMID 9461614

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the ADAM11 mutant, GABAergic release was not altered, but the ultrarapid electrical signal was absent, demonstrating that the dense presynaptic cluster of Kv1 ion channels at these terminals mediate electrical transmission.
      Title: Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.
    2. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
      Title: Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.
    3. ADAM11 may have a role in learning and motor coordination.
      Title: Deficits in spatial learning and motor coordination in ADAM11-deficient mice.
    4. ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.
      Title: Altered nociceptive response in ADAM11-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to acetic acid induced pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to formalin induced pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 11
    Names
    a disintegrin and metalloprotease domain (ADAM) 11
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110778.2 → NP_001104248.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001104248.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AK157926, BC054536
      Consensus CDS
      CCDS48946.1
      UniProtKB/TrEMBL
      Q3TZE2, Q7TQG7
      Related
      ENSMUSP00000069466.6, ENSMUST00000068150.7
      Conserved Domains (6) summary
      smart00608
      Location:534 → 672
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:243 → 440
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:457 → 531
      Disintegrin; Disintegrin
      pfam01421
      Location:243 → 442
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 192
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:681 → 713
      EGF_2; EGF-like domain

    2. NM_001417290.1 → NP_001404219.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL929067
      UniProtKB/TrEMBL
      Q3TZE2

    3. NM_001417291.1 → NP_001404220.1  disintegrin and metalloproteinase domain-containing protein 11 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL929067
      UniProtKB/TrEMBL
      Q3TZE2

    4. NM_009613.3 → NP_033743.2  disintegrin and metalloproteinase domain-containing protein 11 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_033743.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' region, as compared to variant 1. The encoded isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK157926, AL929067, BC054536, CD353697
      Consensus CDS
      CCDS25503.1
      UniProtKB/Swiss-Prot
      A2AUA8, Q9R1V4
      UniProtKB/TrEMBL
      Q3TZE2
      Related
      ENSMUSP00000099370.5, ENSMUST00000103081.10
      Conserved Domains (6) summary
      smart00608
      Location:534 → 672
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:243 → 440
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:457 → 531
      Disintegrin; Disintegrin
      pfam01421
      Location:243 → 442
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 192
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:681 → 713
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102652261..102671089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532017.4 → XP_006532080.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X4

      UniProtKB/TrEMBL
      Q3TZE2
      Conserved Domains (5) summary
      smart00608
      Location:555 → 693
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:702 → 734
      EGF_2; EGF-like domain
      pfam00200
      Location:478 → 551
      Disintegrin
      pfam01421
      Location:264 → 463
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50 → 193
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_006532018.2 → XP_006532081.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X6

      UniProtKB/TrEMBL
      Q3TZE2
      Conserved Domains (5) summary
      smart00608
      Location:555 → 693
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:702 → 734
      EGF_2; EGF-like domain
      pfam00200
      Location:478 → 551
      Disintegrin
      pfam01421
      Location:264 → 463
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50 → 193
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_006532014.2 → XP_006532077.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      Q3TZE2
      Conserved Domains (5) summary
      smart00608
      Location:555 → 693
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:702 → 734
      EGF_2; EGF-like domain
      pfam00200
      Location:478 → 551
      Disintegrin
      pfam01421
      Location:264 → 463
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50 → 193
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_006532016.2 → XP_006532079.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      Q3TZE2
      Conserved Domains (5) summary
      smart00608
      Location:555 → 693
      ACR; ADAM Cysteine-Rich Domain
      pfam07974
      Location:702 → 734
      EGF_2; EGF-like domain
      pfam00200
      Location:478 → 551
      Disintegrin
      pfam01421
      Location:264 → 463
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:50 → 193
      Pep_M12B_propep; Reprolysin family propeptide

    5. XM_030245479.2 → XP_030101339.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X10

      Conserved Domains (3) summary
      smart00608
      Location:276 → 414
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:199 → 272
      Disintegrin
      pfam01421
      Location:1 → 184
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease

    6. XM_006532020.4 → XP_006532083.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X9

      Conserved Domains (3) summary
      smart00608
      Location:330 → 468
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:253 → 326
      Disintegrin
      pfam01421
      Location:39 → 238
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease

    7. XM_017314225.2 → XP_017169714.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X8

      Conserved Domains (3) summary
      smart00608
      Location:389 → 527
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:312 → 385
      Disintegrin
      pfam01421
      Location:98 → 297
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease

    8. XM_006532019.2 → XP_006532082.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X7

      Conserved Domains (3) summary
      smart00608
      Location:389 → 527
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:312 → 385
      Disintegrin
      pfam01421
      Location:98 → 297
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease

    RNA

    1. XR_388328.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1V4.2 GenPept UniProtKB/Swiss-Prot:Q9R1V4

    Gene LinkOut

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