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    RBP5 retinol binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 83758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RBP5provided by HGNC
    Official Full Name
    retinol binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:15847
    See related
    Ensembl:ENSG00000139194 MIM:611866; AllianceGenome:HGNC:15847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRBP3; CRBPIII; HRBPiso; CRBP-III
    Summary
    The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in kidney (RPKM 131.3), liver (RPKM 58.1) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See RBP5 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7115736..7130005, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7130477..7143159, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7276282..7282601, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7188509-7189008 Neighboring gene Sharpr-MPRA regulatory region 13442 Neighboring gene complement C1r Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:7260830-7262029 Neighboring gene complement C1r subcomponent like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7265863-7266364 Neighboring gene C1RL antisense RNA 1 Neighboring gene RNA, U6 small nuclear 485, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7283265-7283766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4199 Neighboring gene calsyntenin 3 Neighboring gene Sharpr-MPRA regulatory region 5519 Neighboring gene uncharacterized LOC124902869 Neighboring gene MPRA-validated peak1553 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7340767-7341268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7341269-7341768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342139-7342855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342856-7343571 Neighboring gene peroxisomal biogenesis factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma. Ho JC, et al. J Cancer Res Clin Oncol, 2007 Dec. PMID 17497168
    2. Evolution of the family of intracellular lipid binding proteins in vertebrates. Schaap FG, et al. Mol Cell Biochem, 2002 Oct. PMID 12479570
    3. Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Folli C, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274389, Free PMC Article
    4. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. Kim JY, et al. Mol Cell, 2014 May 22. PMID 24793694, Free PMC Article
    5. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Maio N, et al. Cell Metab, 2017 Apr 4. PMID 28380382

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our study revealed that RBP5 down-regulation in HCC was associated with aggressive tumor features, suggesting an
      Title: Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinol-binding protein 5
    Names
    cellular retinol-binding protein III
    putative cellular retinol-binding protein CRBP III
    retinol binding protein 5, cellular

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329454.2 → NP_001316383.1  retinol-binding protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC018653, AC233309

    2. NM_031491.4 → NP_113679.1  retinol-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_113679.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA912830, BC029355
      Consensus CDS
      CCDS8574.1
      UniProtKB/Swiss-Prot
      P82980, Q53FB1
      Related
      ENSP00000266560.3, ENST00000266560.8
      Conserved Domains (1) summary
      pfam00061
      Location:6 → 105
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      7115736..7130005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020002.2 → XP_016875491.1  retinol-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam00061
      Location:14 → 92
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. XM_047429633.1 → XP_047285589.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233
      Related
      ENSP00000438083.1, ENST00000542370.1

    RNA

    1. XR_007063133.1 RNA Sequence

    2. XR_001748882.2 RNA Sequence

    3. XR_007063132.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160008.1 Reference GRCh38.p14 PATCHES

      Range
      44978..57956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332544.1 → XP_054188519.1  retinol-binding protein 5 isoform X1

    2. XM_054332545.1 → XP_054188520.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233

    RNA

    1. XR_008485780.1 RNA Sequence

    2. XR_008485778.1 RNA Sequence

    3. XR_008485779.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      7130477..7143159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373385.1 → XP_054229360.1  retinol-binding protein 5 isoform X1

    2. XM_054373386.1 → XP_054229361.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233

    RNA

    1. XR_008488690.1 RNA Sequence

    2. XR_008488688.1 RNA Sequence

    3. XR_008488689.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82980.3 GenPept UniProtKB/Swiss-Prot:P82980

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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