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    MKRN2 makorin ring finger protein 2 [ Homo sapiens (human) ]

    Gene ID: 23609, updated on 10-Dec-2024

    Summary

    Official Symbol
    MKRN2provided by HGNC
    Official Full Name
    makorin ring finger protein 2provided by HGNC
    Primary source
    HGNC:HGNC:7113
    See related
    Ensembl:ENSG00000075975 MIM:608426; AllianceGenome:HGNC:7113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF62; HSPC070
    Summary
    This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in testis (RPKM 30.6), thyroid (RPKM 16.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MKRN2 in Genome Data Viewer
    Location:
    3p25.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12557087..12583713)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12554891..12582517)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12598586..12625212)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12558643-12559143 Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene RNA, U6 small nuclear 377, pseudogene Neighboring gene MKRN2 opposite strand Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14065 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12598813-12599336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19446 Neighboring gene MPRA-validated peak4543 silencer Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12684584-12684794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12698025-12698668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12704698-12705308 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12705309-12705920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12711892-12712473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12712474-12713054 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12715375-12716244 Neighboring gene cysteine rich protein 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of makorin ring finger protein 2 (MKRN2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription  
    involved_in cell differentiation  
    involved_in negative regulation of inflammatory response to antigenic stimulus  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein polyubiquitination  
    involved_in protein ubiquitination  
    involved_in spermatogenesis  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase makorin-2
    Names
    RING finger protein 62
    RING-type E3 ubiquitin transferase makorin-2
    makorin RING zinc-finger protein 2
    probable E3 ubiquitin-protein ligase makorin-2
    NP_001258636.1
    NP_054879.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271707.2NP_001258636.1  E3 ubiquitin-protein ligase makorin-2 isoform 2

      See identical proteins and their annotated locations for NP_001258636.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK298463, BC015715
      Consensus CDS
      CCDS63545.1
      UniProtKB/TrEMBL
      C9J494
      Related
      ENSP00000396340.1, ENST00000411987.5
      Conserved Domains (2) summary
      PHA03096
      Location:135284
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:195249
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_014160.5NP_054879.3  E3 ubiquitin-protein ligase makorin-2 isoform 1

      See identical proteins and their annotated locations for NP_054879.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK298463, BC015715
      Consensus CDS
      CCDS33702.1
      UniProtKB/Swiss-Prot
      A6NIA2, B3KRC5, B4DPR4, Q8N391, Q96BD4, Q9BUY2, Q9H000, Q9NRY1
      UniProtKB/TrEMBL
      A0A7I2YQI0
      Related
      ENSP00000170447.7, ENST00000170447.12
      Conserved Domains (3) summary
      smart00356
      Location:3555
      ZnF_C3H1; zinc finger
      PHA03096
      Location:178327
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:238292
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      12557087..12583713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      12554891..12582517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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