ATF7 activating transcription factor 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATF7provided by HGNC
Official Full Name: activating transcription factor 7provided by HGNC
Primary source: HGNC:HGNC:792
See related: Ensembl:ENSG00000170653 MIM:606371; AllianceGenome:HGNC:792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATFA
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung (RPKM 9.8), fat (RPKM 9.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (53507856..53626382, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (53473861..53592424, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (53901640..54020166, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p.
Title: lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p.
Results found that ATF7 is upregulated in hepatocellular carcinoma (HCC) tissue. Its expression is regulated by miR-340 which directly binds to the mRNA encoding ATF7. Under HBV infection, miR-340 is downregulated resulting in increasing ATF7 expression, leading to enhanced cell proliferation and inhibition of apoptosis.
Title: Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.
ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression.
Title: miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro.
knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved
Title: Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
Title: CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression.
Title: ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.
It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC.
Title: Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer.
These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling.
Title: Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.
ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Data show that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors.
Title: A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-8969 (e-PCR)
- UniSTS:8743

SHGC-57261 (e-PCR)
- UniSTS:31791

STS-R37637 (e-PCR)
- UniSTS:3678

D12S884 (e-PCR)
- UniSTS:149897

D12S887 (e-PCR)
- UniSTS:149900

RH18103 (e-PCR)
- UniSTS:9875

RH44962 (e-PCR)
- UniSTS:76185

RH102598 (e-PCR)
- UniSTS:96932

STS-R96214 (e-PCR)
- UniSTS:19432

Readthrough ATF7-NPFF

Readthrough gene: ATF7-NPFF, Included gene: NPFF

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-7

Names: transcription factor ATF-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130060.2 → NP_001123532.1 cyclic AMP-dependent transcription factor ATF-7 isoform 3

See identical proteins and their annotated locations for NP_001123532.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in an internal exon, compared to variant 2, resulting in a shorter isoform (3, also known as ATFa1 or ATF-a delta), compared to isoform 2. There are no publicly available transcripts representing this variant; it is supported by data in PMIDs 1694576 and 8939888, and by alternative splicing annotation on accessions X52943.1 and X57197.1.

Source sequence(s)

AC023509, BP279417, BP312300, BQ184780, DB047160, X52943

UniProtKB/TrEMBL

B2R8U0

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:313 → 373

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001206682.2 → NP_001193611.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4

See identical proteins and their annotated locations for NP_001193611.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 2, resulting in an isoform (4) with a distinct and shorter C-terminus, compared to isoform 2. Variants 4, 5, and 13 all encode the same isoform (4).

Source sequence(s)

AA679547, BC140006, DB047160

Consensus CDS

CCDS58238.1

UniProtKB/Swiss-Prot

P17544

Related

ENSP00000465192.1, ENST00000591397.1

Conserved Domains (1) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain
NM_001206683.1 → NP_001193612.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4

See identical proteins and their annotated locations for NP_001193612.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 2, resulting in an isoform (4) with a distinct and shorter C-terminus, compared to isoform 2. Variants 4, 5, and 13 all encode the same isoform (4).

Source sequence(s)

AA679547, AC023509, BC042363, DB490927

Consensus CDS

CCDS58238.1

UniProtKB/Swiss-Prot

P17544

Related

ENSP00000456858.1, ENST00000548118.6

Conserved Domains (1) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain
NM_001366555.2 → NP_001353484.1 cyclic AMP-dependent transcription factor ATF-7 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (7) encodes the longest isoform (5).

Source sequence(s)

AC023509, AC073594

Consensus CDS

CCDS44905.1

UniProtKB/TrEMBL

B2R8U0

Related

ENSP00000449938.1, ENST00000548446.6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:345 → 405

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001366556.2 → NP_001353485.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (8), as well as variants 2 and 9, encodes isoform 2.

Source sequence(s)

AC023509, AC073594

Consensus CDS

CCDS44906.1

UniProtKB/Swiss-Prot

A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83

UniProtKB/TrEMBL

B2R8U0

Related

ENSP00000387406.3, ENST00000456903.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001366558.2 → NP_001353487.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variants 2 and 8, encodes isoform 2.

Source sequence(s)

AC023509, AC073594

Consensus CDS

CCDS44906.1

UniProtKB/Swiss-Prot

A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83

UniProtKB/TrEMBL

B2R8U0

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001366561.2 → NP_001353490.1 cyclic AMP-dependent transcription factor ATF-7 isoform 8

Status: VALIDATED

Source sequence(s)

AC023509, AC073594

UniProtKB/TrEMBL

B2R8U0

Conserved Domains (1) summary

cd14687
Location:279 → 339

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_001366562.2 → NP_001353491.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (13), as well as variants 4 and 5, encodes isoform 4.

Source sequence(s)

AC023509, AC073594

Consensus CDS

CCDS58238.1

Conserved Domains (1) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain
NM_001366563.2 → NP_001353492.1 cyclic AMP-dependent transcription factor ATF-7 isoform 9

Status: VALIDATED

Source sequence(s)

AC023509, AC073594

Conserved Domains (1) summary

cd12192
Location:18 → 54

GCN4_cent; GCN4 central activation domain-like acidic activation domain
NM_006856.3 → NP_006847.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2

See identical proteins and their annotated locations for NP_006847.1

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variants 8 and 9, encodes isoform 2 (also known as ATFa2).

Source sequence(s)

AC023509, BP279417, BP312300, BQ184780, DB047160, X52943

Consensus CDS

CCDS44906.1

UniProtKB/Swiss-Prot

A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83

UniProtKB/TrEMBL

B2R8U0

Related

ENSP00000399465.1, ENST00000420353.7

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:334 → 394

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

NR_073163.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) use an alternate splice site in an internal exon and has an alternate 3' structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC073594, AK298853

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

53507856..53626382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

53473861..53592424 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001130059.1: Suppressed sequence

Description

NM_001130059.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.