Acsm3 acyl-CoA synthetase medium-chain family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsm3provided by RGD
Official Full Name: acyl-CoA synthetase medium-chain family member 3provided by RGD
Primary source: RGD:62086
See related: EnsemblRapid:ENSRNOG00000032246 AllianceGenome:RGD:62086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sa; Sah
Summary: Predicted to enable fatty-acyl-CoA synthase activity; medium-chain fatty acid-CoA ligase activity; and propionate CoA-transferase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Used to study hypertension. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 395.7), Liver (RPKM 225.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183564652..183591328)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (174133260..174159966)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189514504..189541233)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation.
Title: Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation.

Submit: New GeneRIF Correction

General gene information

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Markers

BE108110 (e-PCR)
- UniSTS:247646

D1Wox50 (e-PCR)
- UniSTS:518758

D1Mco13 (e-PCR)
- UniSTS:240493

D1Mco14 (e-PCR)
- UniSTS:240494

RH144126 (e-PCR)
- UniSTS:233372

BE098160 (e-PCR)
- UniSTS:245187

D1Wox49 (e-PCR)
- UniSTS:518890

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-methylbutanoate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fatty acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid ligase activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionate CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables propionate CoA-transferase activity	ISO Inferred from Sequence Orthology more info
enables propionate-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acyl-coenzyme A synthetase ACSM3, mitochondrial

Names: SA hypertension-associated homolog; SA rat hypertension-associated homolog; SA rat hypertension-associated protein; butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3; middle-chain acyl-CoA synthetase 3; propionate--CoA ligase; protein SA; ssubA

NP_150234.1

EC 6.2.1.17

EC 6.2.1.2

XP_006230168.1

EC 6.2.1.17

EC 6.2.1.2

XP_038956744.1

EC 6.2.1.17

EC 6.2.1.2

XP_063137105.1

EC 6.2.1.17

EC 6.2.1.2

XP_063137107.1

EC 6.2.1.17

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033231.1 → NP_150234.1 acyl-coenzyme A synthetase ACSM3, mitochondrial

See identical proteins and their annotated locations for NP_150234.1

Status: PROVISIONAL

Source sequence(s)

BC090325

UniProtKB/Swiss-Prot

Q62742, Q6SKG1

UniProtKB/TrEMBL

A0A8I6G5I9, A6I8M8

Related

ENSRNOP00000020039.6, ENSRNOT00000020039.8

Conserved Domains (1) summary

cd05928
Location:48 → 577

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

183564652..183591328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230106.5 → XP_006230168.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006230168.1

UniProtKB/TrEMBL

A0A8I6G5I9

Conserved Domains (2) summary

COG0365
Location:45 → 575

Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]

cl17068
Location:48 → 578

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_063281037.1 → XP_063137107.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X4
XM_039100816.2 → XP_038956744.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I6G5I9

Conserved Domains (1) summary

cd05928
Location:41 → 571

MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)
XM_063281035.1 → XP_063137105.1 acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X3