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    Mrpl58 mitochondrial ribosomal protein L58 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl58provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L58provided by RGD
    Primary source
    RGD:1307942
    See related
    EnsemblRapid:ENSRNOG00000032780 AllianceGenome:RGD:1307942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ict1
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific. Predicted to be involved in mitochondrial translational termination and rescue of stalled ribosome. Predicted to be located in mitochondrion; nucleoplasm; and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 339.8), Testes (RPKM 288.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl58 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101145342..101151838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100646374..100652871)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103956019..103962515)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HID1 domain containing Neighboring gene uncharacterized LOC134480902 Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene transfer RNA arginine (anticodon CCU) 7 Neighboring gene transfer RNA arginine (anticodon CCU) 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Richter R, et al. EMBO J, 2010 Mar 17. PMID 20186120, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity, codon nonspecific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity, codon nonspecific ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL62
    Names
    immature colon carcinoma transcript 1
    peptidyl-tRNA hydrolase ICT1, mitochondrial
    NP_001178585.1
    XP_038942124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191656.1 → NP_001178585.1  large ribosomal subunit protein mL62 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZDP2
      Related
      ENSRNOP00000085915.1, ENSRNOT00000118784.2
      Conserved Domains (1) summary
      cl23917
      Location:72 → 202
      RF-1; RF-1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101145342..101151838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086196.2 → XP_038942124.1  large ribosomal subunit protein mL62 isoform X1

      Conserved Domains (1) summary
      cl29584
      Location:19 → 149
      RF-1; RF-1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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