Cdc25b cell division cycle 25B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc25bprovided by MGI
Official Full Name: cell division cycle 25Bprovided by MGI
Primary source: MGI:MGI:99701
See related: Ensembl:ENSMUSG00000027330 AllianceGenome:MGI:99701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex ventricular layer; gonad; placenta; and primitive collecting duct. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 81.1), liver E14 (RPKM 67.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.29 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (131028356..131040431)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (131186436..131198511)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of G2 Phase Duration by CDC25B Modulates the Switch from Direct to Indirect Neurogenesis in the Neocortex.
Title: Control of G(2) Phase Duration by CDC25B Modulates the Switch from Direct to Indirect Neurogenesis in the Neocortex.
CDC25B is required for the metaphase I-metaphase II transition in mouse oocytes.
Title: CDC25B is required for the metaphase I-metaphase II transition in mouse oocytes.
CDC25B is required for efficient neuron production in vertebrates.
Title: Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase.
data suggest an important role of CDC25B for microtubule nucleation and organization. N-terminal of CDC25B is required for regulating the microtubule dynamics and mitotic function.
Title: CDC25B is involved in the centrosomal microtubule nucleation in two-cell stage mouse embryos.
LSD1 is essential for oocyte meiotic progression by upregulating CDC25B expression.
Title: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.
The role of Cdc25c and Cdc25b in activating G2/M cell cycle checkpoint in zygote.
Title: Phospho-Cdc25 correlates with activating G2/M checkpoint in mouse zygotes fertilized with hydrogen peroxide-treated mouse sperm.
AURKA induced phosphorylation and recruitment of CDC25B to MTOCs prior to p-Cyclin B1-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.
Title: Successive recruitment of p-CDC25B-Ser351 and p-cyclin B1-Ser123 to centrosomes contributes to the release of mouse oocytes from prophase I arrest.
Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B in cytoplasm. Its binding to CDC25B-S321 phosphorylated by PKA induces mitotic arrest.
Title: 14-3-3 epsilon prevents G2/M transition of fertilized mouse eggs by binding with CDC25B.
contributes to metaphase arrest in mouse oocytes
Title: Cdc25B phosphatase participates in maintaining metaphase II arrest in mouse oocytes.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
Title: The role of 14-3-3ε interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrest.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234530

AI604853 (e-PCR)
- UniSTS:164180

Cdc25b (e-PCR), detects polymorphism
- UniSTS:276140

RH131478 (e-PCR)
- UniSTS:214761

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: M-phase inducer phosphatase 2

Names: dual specificity phosphatase Cdc25B

NP_001104545.1

EC 3.1.3.48

NP_075606.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111075.4 → NP_001104545.1 M-phase inducer phosphatase 2 isoform b

See identical proteins and their annotated locations for NP_001104545.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame coding exon and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AL808128, AL831736, BC057568

Consensus CDS

CCDS50717.1

UniProtKB/TrEMBL

Q3TZX9, Q9DBN8

Related

ENSMUSP00000078784.9, ENSMUST00000079857.9

Conserved Domains (2) summary

cd01530
Location:382 → 501

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:111 → 353

M-inducer_phosp; M-phase inducer phosphatase
NM_023117.4 → NP_075606.1 M-phase inducer phosphatase 2 isoform a

See identical proteins and their annotated locations for NP_075606.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AL808128, AL831736, BC057568, BQ561430, W54021

Consensus CDS

CCDS16758.1

UniProtKB/Swiss-Prot

P30306, Q99LP3

UniProtKB/TrEMBL

Q3TZX9, Q3U535

Related

ENSMUSP00000028804.9, ENSMUST00000028804.15

Conserved Domains (2) summary

cd01530
Location:408 → 527

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:111 → 379

M-inducer_phosp; M-phase inducer phosphatase