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    Hrh1 histamine receptor H1 [ Mus musculus (house mouse) ]

    Gene ID: 15465, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Hrh1provided by MGI
    Official Full Name
    histamine receptor H1provided by MGI
    Primary source
    MGI:MGI:107619
    See related
    Ensembl:ENSMUSG00000053004 AllianceGenome:MGI:107619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H1R; Hir; Bphs; HH1R
    Summary
    Predicted to enable calcium ion transmembrane transporter activity; histamine binding activity; and histamine receptor activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol. Predicted to be active in dendrite and plasma membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hrh1 in Genome Data Viewer
    Location:
    6 E3; 6 53.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114374897..114459432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114397936..114483298)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Neighboring gene predicted gene, 38875 Neighboring gene STARR-positive B cell enhancer ABC_E9098 Neighboring gene autophagy related 7 Neighboring gene STARR-seq mESC enhancer starr_17063 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression. Noubade R, et al. J Immunol, 2008 Jun 1. PMID 18490747, Free PMC Article
    2. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. Aritake K, et al. J Biol Chem, 2006 Jun 2. PMID 16547010
    3. The H1 histamine receptor regulates allergic lung responses. Bryce PJ, et al. J Clin Invest, 2006 Jun. PMID 16680192, Free PMC Article
    4. Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model. Miyamoto K, et al. Int Arch Allergy Immunol, 2006. PMID 16685135
    5. Contribution of histamine type-1 receptor to metabolic and behavioral control of ventilation. Ishiguro T, et al. J Physiol Sci, 2006 Aug. PMID 16875510

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comprehensive mapping of histamine H1 receptor mRNA in the mouse brain.
      Title: Comprehensive mapping of histamine H(1) receptor mRNA in the mouse brain.
    2. Disruption of Histamine-H1R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFkappaB-p65 pathway.
      Title: Disruption of Histamine-H(1)R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway.
    3. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
      Title: TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
    4. The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
      Title: The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
    5. effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization
      Title: The effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization.
    6. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons.
      Title: A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H(1) receptors.
    7. Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges
      Title: Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.
    8. this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy
      Title: The antihistamine olopatadine regulates T cell activation in palladium allergy.
    9. Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice.
      Title: Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.
    10. The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
      Title: Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables histamine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histamine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to histamine ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in cellular response to histamine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histamine H1 receptor
    Names
    Bordetella pertussis induced histamine sensitization

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252642.3 → NP_001239571.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001239571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124460.2, ENSMUST00000161650.3
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001252643.3 → NP_001239572.1  histamine H1 receptor

      See identical proteins and their annotated locations for NP_001239572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124037.2, ENSMUST00000161220.2
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001317124.2 → NP_001304053.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000124320.2, ENSMUST00000160780.2
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001317125.2 → NP_001304054.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001317126.2 → NP_001304055.1  histamine H1 receptor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. Variants 1 thorugh 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_001410031.1 → NP_001396960.1  histamine H1 receptor

      Status: VALIDATED

      Source sequence(s)
      AC159381
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0

    7. NM_008285.5 → NP_032311.2  histamine H1 receptor

      See identical proteins and their annotated locations for NP_032311.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
      Source sequence(s)
      AC159381
      Consensus CDS
      CCDS20435.1
      UniProtKB/Swiss-Prot
      P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
      UniProtKB/TrEMBL
      B3Y5T0
      Related
      ENSMUSP00000086383.3, ENSMUST00000088987.3
      Conserved Domains (1) summary
      cd15050
      Location:29 → 480
      7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      114374897..114459432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70174.2 GenPept UniProtKB/Swiss-Prot:P70174

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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