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    P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 [ Mus musculus (house mouse) ]

    Gene ID: 231602, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2rx2provided by MGI
    Official Full Name
    purinergic receptor P2X, ligand-gated ion channel, 2provided by MGI
    Primary source
    MGI:MGI:2665170
    See related
    Ensembl:ENSMUSG00000029503 AllianceGenome:MGI:2665170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2x2; P2X2a
    Summary
    Enables extracellularly ATP-gated monoatomic cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including neuromuscular synaptic transmission; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is active in neuronal dense core vesicle. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Used to study autosomal dominant nonsyndromic deafness 41. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues See more
    Orthologs
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    Genomic context

    See P2rx2 in Genome Data Viewer
    Location:
    5 F; 5 53.49 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110487678..110491186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110339812..110343320, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene peroxisomal membrane protein 2 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277 Neighboring gene leucine rich colipase-like 1 Neighboring gene fibrosin-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC129148, MGC129149

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables cadmium ion binding  
    enables cobalt ion binding  
    enables copper ion binding  
    enables extracellularly ATP-gated monoatomic cation channel activity  
    enables extracellularly ATP-gated monoatomic cation channel activity PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity  
    enables identical protein binding  
    enables identical protein binding  
    enables ligand-gated monoatomic ion channel activity  
    enables mercury ion binding  
    enables nickel cation binding  
    enables phosphatidylinositol binding  
    enables protein-containing complex binding  
    enables purinergic nucleotide receptor activity  
    enables purinergic nucleotide receptor activity  
    enables suramin binding  
    enables zinc ion binding  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral response to pain PubMed 
    acts_upstream_of_or_within behavioral response to pain PubMed 
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within chemical synaptic transmission PubMed 
    acts_upstream_of_or_within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling PubMed 
    involved_in excitatory postsynaptic potential  
    involved_in monoatomic cation transmembrane transport  
    acts_upstream_of_or_within neuromuscular junction development PubMed 
    acts_upstream_of_or_within neuromuscular synaptic transmission PubMed 
    involved_in neuronal action potential  
    acts_upstream_of_or_within peristalsis PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in purinergic nucleotide receptor signaling pathway  
    involved_in regulation of presynaptic cytosolic calcium ion concentration  
    involved_in regulation of synaptic vesicle exocytosis  
    acts_upstream_of_or_within response to ATP PubMed 
    acts_upstream_of_or_within response to ATP PubMed 
    acts_upstream_of_or_within response to carbohydrate PubMed 
    acts_upstream_of_or_within response to hypoxia PubMed 
    involved_in response to ischemia  
    involved_in response to organic cyclic compound  
    involved_in sensory perception of sound PubMed 
    involved_in sensory perception of sound  
    acts_upstream_of_or_within sensory perception of taste PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development PubMed 
    acts_upstream_of_or_within urinary bladder smooth muscle contraction PubMed 
    acts_upstream_of_or_within urinary bladder smooth muscle contraction PubMed 
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in cell surface  
    located_in dendritic spine  
    is_active_in glutamatergic synapse  
    located_in intracellular anatomical structure PubMed 
    located_in neuronal cell body  
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in neuronal dense core vesicle PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in presynaptic active zone membrane  
    located_in presynaptic membrane  
    part_of receptor complex  
    part_of receptor complex PubMed 
    located_in terminal bouton  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164833.1NP_001158305.1  P2X purinoceptor 2 isoform b

      See identical proteins and their annotated locations for NP_001158305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AB094664, BY236715
      Consensus CDS
      CCDS51608.1
      UniProtKB/Swiss-Prot
      Q8K3P1
      Related
      ENSMUSP00000108097.4, ENSMUST00000112478.8
      Conserved Domains (1) summary
      TIGR00863
      Location:14380
      P2X; cation transporter protein
    2. NM_001164834.1NP_001158306.1  P2X purinoceptor 2 isoform c

      See identical proteins and their annotated locations for NP_001158306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment in the 3' coding region compared to variant 1. The encoded protein (isoform e) is shorter than isoform a.
      Source sequence(s)
      AB094663, BY236715
      Consensus CDS
      CCDS80362.1
      UniProtKB/Swiss-Prot
      Q8K3P1
      Related
      ENSMUSP00000143554.2, ENSMUST00000200037.5
      Conserved Domains (1) summary
      TIGR00863
      Location:14380
      P2X; cation transporter protein
    3. NM_001310700.1NP_001297629.1  P2X purinoceptor 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform 1.
      Source sequence(s)
      AK141196, AK158334, BY236715, BY595018
      Consensus CDS
      CCDS80363.1
      UniProtKB/Swiss-Prot
      Q8K3P1
      Related
      ENSMUSP00000054233.11, ENSMUST00000058016.16
      Conserved Domains (2) summary
      TIGR00863
      Location:14392
      P2X; cation transporter protein
      pfam06409
      Location:399458
      NPIP; Nuclear pore complex interacting protein (NPIP)
    4. NM_001310701.1NP_001297630.1  P2X purinoceptor 2 isoform e

      See identical proteins and their annotated locations for NP_001297630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AC123699
      Consensus CDS
      CCDS80361.1
      UniProtKB/Swiss-Prot
      Q8K3P1
      Related
      ENSMUSP00000142567.2, ENSMUST00000200214.2
      Conserved Domains (1) summary
      cl02993
      Location:1293
      P2X_receptor; ATP P2X receptor
    5. NM_153400.4NP_700449.2  P2X purinoceptor 2 isoform a

      See identical proteins and their annotated locations for NP_700449.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AB094663, AB094664, AK141196, BY236715
      Consensus CDS
      CCDS51607.1
      UniProtKB/Swiss-Prot
      Q3KP15, Q3TYV0, Q812E6, Q812E7, Q8K3P1
      Related
      ENSMUSP00000143047.2, ENSMUST00000195985.5
      Conserved Domains (2) summary
      TIGR00863
      Location:14380
      P2X; cation transporter protein
      pfam06409
      Location:387446
      NPIP; Nuclear pore complex interacting protein (NPIP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110487678..110491186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534921.4XP_006534984.1  P2X purinoceptor 2 isoform X2

      See identical proteins and their annotated locations for XP_006534984.1

      Conserved Domains (1) summary
      cl02993
      Location:5299
      P2X_receptor; ATP P2X receptor
    2. XM_006534920.4XP_006534983.1  P2X purinoceptor 2 isoform X1

      Conserved Domains (1) summary
      TIGR00863
      Location:14392
      P2X; cation transporter protein
    3. XM_011249448.2XP_011247750.1  P2X purinoceptor 2 isoform X3

      See identical proteins and their annotated locations for XP_011247750.1

      UniProtKB/Swiss-Prot
      Q8K3P1
      Conserved Domains (1) summary
      cl02993
      Location:1293
      P2X_receptor; ATP P2X receptor
    4. XM_011249447.3XP_011247749.1  P2X purinoceptor 2 isoform X2

      See identical proteins and their annotated locations for XP_011247749.1

      Conserved Domains (1) summary
      cl02993
      Location:5299
      P2X_receptor; ATP P2X receptor
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